Axel A. Brakhage

Prof. Dr. Axel A. Brakhage

Direktorat · Direktor Molekulare und Angewandte Mikrobiologie · Abteilungsleiter

Telefon: +49 3641 532-1001 Telefax: +49 3641 532-0802 E-Mail: axel.brakhage@leibniz-hki.de

Forschungsschwerpunkte
  • Infektionsbiologie von human-pathogenen Pilzen
  • Molekulare Biotechnologie/Synthetische Biotechnologie mikrobieller Wirkstoffe
  • Mikrobielle Kommunikation
  • Eukaryotische Genregulation/Transkriptionsfaktoren
Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

seit 2005 Wissenschaftlicher Direktor, Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie-Hans-Knöll-Institut (HKI) Jena
seit 2005 Abteilungsleiter Molekulare und Angewandte Mikrobiologie, HKI Jena
seit 2004 Professor (C4/W3) und Lehrstuhl für Mikrobiologie und Molekularbiologie, Institut für Mikrobiologie, FSU Jena
2001-2004 Professor (C4) und Lehrstuhl für Mikrobiologie, Leibniz Universität Hannover
1998-2001 Professor (C3) für Mikrobiologie, Technische Universität Darmstadt
1996 Habilitation in Mikrobiologie, Ludwig-Maximilians-Universität München
1992-1998 Assistent(C1), Institut für Genetik und Mikrobiologie, Ludwig-Maximilians-Universität München
1990-1992 Wiss. Mitarbeiter, The University of Sheffield, UK, gefördert durch ein Postdoktoranden-Stipendium der DFG
1989-1990 Gruppenleiter, Biotechnologie, BASF AG, Ludwigshafen
1989 Dr. rer. nat. in Mikrobiologie, „summa cum laude“ Universität Münster und Institut de Biologie Physico-Chimique (IBPC) Paris
1985 Studium Biologie/Chemie, Diplom in Biologie an der Westfälischen Wilhelms-Universität Münster

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

seit 2017 gewähltes Mitglied American Academy of Microbiology
seit 2017 Mitglied des Wiss. Beirats der Robert-Koch-Stiftung (RKS), Berlin
seit 2017 Mitglied des Wiss. Beirats des MRC Medical Mycology Centre, Aberdeen, UK
seit 2016 Mitglied des Wiss. Beirats des Max-Planck-Instituts für Infektionsbiologie (MPIIB), Berlin
seit 2015 gewähltes Mitglied European Academy of Microbiology
seit 2015 Ehrenmitgliedschaft Deutschsprachige Mykologische Gesellschaft (DMykG)
2014 Haupt-Forschungspreis Deutsche Gesellschaft für Hygiene + Mikrobiologie (DGHM)
seit 2013 Sprecher des SFB/Transregio 124 FungiNet (DFG)
seit 2013 stellv. Sprecher des Leibniz-Forschungsverbundes Wirkstoffe und Biotechnologie
seit 2013 Vorstandsmitglied des Forschungscampus “InfectoGnostics” (BMBF)
seit 2012 Sprecher “InfectControl 2020- Neue Antiinfektionsstrategien-Wissenschaft • Gesellschaft • Wirtschaft” im BMBF-Programm “Zwanzig 20-Partnerschaft für Innovation”
2012-2016 Sprecher des DFG-Fachkollegiums 204 Mikrobiologie, Immunologie, Virologie
2010-2012 Vorstandsmitglied des Integrierten Forschungs- und Behandlungszentrums “Center for Sepsis Control and Care” (CSCC) am Universitätsklinikum Jena
seit 2010 Sprecher (u. Präsidiumsbeauftragter) des Leibniz Research Clusters “Biotechnologie 2020+“
seit 2010 Mitglied des Wiss. Beirats des Helmholtz-Zentrums für Infektionsforschung (HZI), Braunschweig
seit 2010 Mitglied des Wiss. Beirats des Helmholtz-Instituts für Pharmazeutische Wissenschaften (HIPS), Saarbrücken
seit 2010 Mitglied des Wiss. Beirats des Forschungszentrums Borstel, Borstel, stellv. Vorsitzender
seit 2009 Mitglied des Wiss. Beirats des Interdisziplinären Zentrums für Klinische Forschung der Julius-Maximilians-Universität Würzburg
seit 2009 Aufsichtsrat Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ), Braunschweig
2009-2011 Präsident der Vereinigung für Allgemeine und Angewandte Mikrobiologie
seit 2008 Mitglied des Universitätsrats (Wiederbestellung 2011 + 2015) der Friedrich-Schiller-Universität Jena
2008-2016 Mitglied des DFG-Fachkollegiums 204 Mikrobiologie, Immunologie, Virologie
2008 gewähltes Mitglied der Nationalen Akademie der Wissenschaften, Leopoldina
2007-2016 Vertrauensperson für wiss. Fehlverhalten der FSU Jena
seit 2007 Sprecher der Exzellenzgraduiertenschule „Jena School for Microbial Communication”
2006-2008 Sprecher der Graduiertenschule "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“
2006 Heinz-Seeliger Preis für Infektionsbiologie
seit 2005 Wiss. Beirat "Goettinger Center for Molecular Bio/Sciences (GZMB)", Georg-August-Universität Göttingen
seit 2005 Mitglied des Fakultätsrats der Biologisch-Pharmazeutischen Fakultät, FSU Jena
2004-2010 Sprecher des DFG Schwerpunktprogramms 1160 "Kolonisation und Infektion durch human-pathogene Pilze"
2003-2010 Wiss. Beirat „Center for Microbial Biotechnology“ DTU Kopenhagen, Dänemark
2003-2009 Mitglied im Programmkomitee des DFG Schwerpunktprogramms 1152 "Evolution of Metabolic Diversity"
2003-2004 Dekan Fachbereich Biologie, Leibniz-Universität Hannover
2002-2006
seit 2009
Mitglied Wiss. Beirat des "Centre for Infectious Diseases", Julius-Maximilians-Universität Würzburg
seit 1998 Editor verschiedener Zeitschriften
seit 1995 Principal investigator in EU Projekten
Publikationen

Bergfeld A, Dasari P, Werner S, Hughes TR, Song WC, Hortschansky P, Brakhage AA, Hünig T, Zipfel PF, Beyersdorf N (2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844. Details PubMed

de Vries RP, Riley R, Wiebenga A, Aguilar-Osorio G, Amillis S, Uchima CA, Anderluh G, Asadollahi M, Askin M, Barry K, Battaglia E, Bayram Ö, Benocci T, Braus-Stromeyer SA, Caldana C, Cánovas D, Cerqueira GC, Chen F, Chen W, Choi C, Clum A, Dos Santos RA, Damásio AR, Diallinas G, Emri T, Fekete E, Flipphi M, Freyberg S, Gallo A, Gournas C, Habgood R, Hainaut M, Harispe ML, Henrissat B, Hildén KS, Hope R, Hossain A, Karabika E, Karaffa L, Karányi Z, Kraševec N, Kuo A, Kusch H, LaButti K, Lagendijk EL, Lapidus A, Levasseur A, Lindquist E, Lipzen A, Logrieco AF, MacCabe A, Mäkelä MR, Malavazi I, Melin P, Meyer V, Mielnichuk N, Miskei M, Molnár ÁP, Mulé G, Ngan CY, Orejas M, Orosz E, Ouedraogo JP, Overkamp KM, Park HS, Perrone G, Piumi F, Punt PJ, Ram AF, Ramón A, Rauscher S, Record E, Riaño-Pachón DM, Robert V, Röhrig J, Ruller R, Salamov A, Salih NS, Samson RA, Sándor E, Sanguinetti M, Schütze T, Sepčić K, Shelest E, Sherlock G, Sophianopoulou V, Squina FM, Sun H, Susca A, Todd RB, Tsang A, Unkles SE, van de Wiele N, van Rossen-Uffink D, Oliveira JV, Vesth TC, Visser J, Yu JH, Zhou M, Andersen MR, Archer DB, Baker SE, Benoit I, Brakhage AA, Braus GH, Fischer R, Frisvad JC, Goldman GH, Houbraken J, Oakley B, Pócsi I, Scazzocchio C, Seiboth B, vanKuyk PA, Wortman J, Dyer PS, Grigoriev IV (2017) Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol 18(1), 28. Details PubMed Open Access

Hortschansky P, Haas H, Huber EM, Groll M, Brakhage AA (2017) The CCAAT-binding complex (CBC) in Aspergillus species. Biochim Biophys Acta 1860(5), 560-570. (Review) Details PubMed

Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ (2017) A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity MBio [In press] Details

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K (2017) Arylmethylamino steroids as antiparasitic agents. Nat Commun 8, 14478. Details PubMed

Manfiolli AO, de Castro PA, Dos Reis TF, Dolan S, Doyle S, Jones G, Riaño Pachón DM, Ulaş M, Noble LM, Mattern DJ, Brakhage AA, Valiante V, Silva-Rocha R, Bayram O, Goldman GH (2017) Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence. Cell Microbiol [Epub ahead of print] Details PubMed

Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM (2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol [Epub ahead of print] Details PubMed

Mattern DJ, Valiante V, Horn F, Petzke L, Brakhage AA (2017) Rewiring of the Austinoid Biosynthetic Pathway in Filamentous Fungi. ACS Chem Biol [Epub ahead of print] Details PubMed

Noßmann M, Pieper J, Hillmann F, Brakhage AA, Munder T (2017) Generation of an arginine-tRNA-adapted Saccharomyces cerevisiae strain for effective heterologous protein expression. Curr Genet [Epub ahead of print] Details PubMed

Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O (2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9 mBio 8(1), e02211-16. Details PubMed

Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarten D, Opitz C, Brakhage AA, Sitek B, Hasenberg M, Gunzer M (2017) Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection. Mol Cell Proteomics [Epub ahead of print] Details PubMed

Shekhova E, Kniemeyer O, Brakhage AA (2017) Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus. Antimicrob Agents Chemother 61(11), Details PubMed

Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA (2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement

Weber J, Valiante V, Nødvig CS, Mattern DJ, Slotkowski RA, Mortensen UH, Brakhage AA (2017) Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing. ACS Synth Biol 6(1), 62-68. Details PubMed

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G (2016) Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe 19(1), 79-90. Details PubMed

Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC (2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12, 419-424. Details PubMed

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A (2016) Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167(4), 1067-1078.e16. Details PubMed

Bruder Nascimento AC, Dos Reis TF, de Castro PA, Hori JI, Bom VL, de Assis LJ, Ramalho LN, Rocha MC, Malavazi I, Brown NA, Valiante V, Brakhage AA, Hagiwara D, Goldman GH (2016) Mitogen activated protein kinases SakA (HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Mol Microbiol 100(5), 841-859. Details PubMed

Chamilos G, Akoumianaki T, Kyrmizi I, Brakhage A, Beauvais A, Latge JP (2016) Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease. Autophagy 12(5), 888-889. (Review) Details PubMed

Fischer J, Schroeckh V, Brakhage AA (2016) Awakening of Fungal Secondary Metabolite Gene Clusters In: Gene Expression Systems in Fungi: Advancements and Applications (Part II), pp. 253-273. Springer. ISBN: 978-3-319-27949. (Review) Details

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ (2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLoS Pathog 12(7), e1005775. Details PubMed

Hillmann F, Bagramyan K, Straßburger M, Heinekamp T, Hong TB, Bzymek KP, Williams JC, Brakhage AA, Kalkum M (2016) The crystal structure of peroxiredoxin Asp f3 provides mechanistic insight into oxidative stress resistance and virulence of Aspergillus fumigatus. Sci Rep 6, 33396. Details PubMed Open Access

Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Scherlach K, Martin K, Brakhage AA, Petzke L, Valiante V (2016) Draft genome sequences of fungus Aspergillus calidoustus. Genome Announc 4(2), e00102-16. Details PubMed

Joehnk B, Bayram O, Valerius O, Heinekamp T, Jacobsen ID, Mattern D, Brakhage AA, Braus G (2016) SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus PLoS Pathogens 12(9), e1005899. Details Open Access PDF

Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D (2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. Chembiochem 17, 1813-1817. Details PubMed

Kniemeyer O, Ebel F, Krüger T, Bacher P, Scheffold A, Luo T, Strassburger M, Brakhage AA (2016) Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies. Proteomics Clin Appl 10(9-10), 910-921. (Review) Details PubMed

Kröber A, Etzrodt S, Bach M, Monod M, Kniemeyer O, Staib P, Brakhage AA (2016) The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae. Curr Genet 63(1), 103-116. Details PubMed

Kröber A, Scherlach K, Hortschansky P, Shelest E, Staib P, Kniemeyer O, Brakhage AA (2016) HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence. PLoS One 11(3), e0150701. Details PubMed

Kroll K, Shekhova E, Mattern DJ, Thywissen A, Jacobsen ID, Strassburger M, Heinekamp T, Shelest E, Brakhage AA, Kniemeyer O (2016) The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus Mol Microbiol 101(1), 92-108. Details PubMed

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406. Details PubMed

Macheleidt J, Mattern DJ, Fischer J, Netzker T, Weber J, Schroeckh V, Valiante V, Brakhage AA (2016) Regulation and Role of Fungal Secondary Metabolites. Annu Rev Genet 50, 371-392. (Review) Details PubMed

Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, de Vries RP, Haarmann T, Hansen K, Hertz-Fowler C, Krappmann S, Mortensen UH, Penalva MA, Ram AFG, Head RM (2016) Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper Fungal Biology and Biotechnology 3(6), (Review) Details Open Access

Mohebbi S, Erfurth F, Hennersdorf P, Brakhage AA, Saluz HP (2016) Hyperspectral imaging using intracellular spies: quantitative real-time measurement of intracellular parameters in vivo during interaction of the pathogenic fungus Aspergillus fumigatus with human monocytes PLOS ONE 11(10), e0163505. Details

Netzker T, Schroeckh V, Gregory MA, Flak M, Krespach MK, Leadlay PF, Brakhage AA (2016) An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35. Appl Environ Microbiol 82(12), 3481-3492. Details PubMed

Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Nature Scientific Reports 6, 27807. Details PubMed Open Access PDF Supplement

Scharf DH, Brakhage AA, Mukherjee PK (2016) Gliotoxin- bane or boon? Environ Microbiol 18(4), 1096-1109. (Review) Details PubMed

Tauber JP, Schroeckh V, Shelest E, Brakhage AA, Hoffmeister D (2016) Bacteria induce pigment formation in the basidiomycete Serpula lacrymans. Environ Microbiol 18, 5218-5227. Details PubMed

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O (2016) Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 15(5), 1580-1591. Details PubMed

Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N (2016) Identification and characterization of a novel Aspergillus fumigatus rhomboid family putative protease RbdA involved in hypoxia sensing and virulence. Infect Immun 84(6), 1866-1878. Details PubMed

Valiante V, Baldin C, Hortschansky P, Jain R, Thywißen A, Straßburger M, Shelest E, Heinekamp T, Brakhage AA (2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol 102(2), 321-335. Details PubMed

Altwasser R, Baldin C, Weber J, Guthke R, Kniemeyer O, Brakhage AA, Linde J, Valiante V (2015) Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus. PLoS One 10(9), e0136932. Details PubMed Open Access

Bacher P, Jochheim-Richter A, Mockel-Tenbrink N, Kniemeyer O, Wingenfeld E, Alex R, Ortigao A, Karpova D, Lehrnbecher T, Ullmann AJ, Hamprecht A, Cornely O, Brakhage AA, Assenmacher M, Bonig H, Scheffold A (2015) Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer. Cytotherapy 17(10), 1396-1405. Details PubMed

Bacher P, Steinbach A, Kniemeyer O, Hamprecht A, Assenmacher M, Vehreschild MJ, Vehreschild JJ, Brakhage AA, Cornely OA, Scheffold A (2015) Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold infection. Am J Respir Crit Care Med 191(3), 348-352. Details PubMed

Baldin C, Valiante V, Krüger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA (2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13), 2230-2243. Details PubMed

Gallmetzer A, Silvestrini L, Schinko T, Gesslbauer B, Hortschansky P, Dattenböck C, Muro-Pastor MI, Kungl A, Brakhage AA, Scazzocchio C, Strauss J (2015) Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLoS Genet 11(7), e1005297. Details PubMed Open Access

Heinekamp T, Schmidt H, Lapp K, Pähtz V, Shopova I, Köster-Eiserfunke N, Krüger T, Kniemeyer O, Brakhage AA (2015) Interference of Aspergillus fumigatus with the immune response. Semin Immunopathol 37(2), 141-152. (Review) Details PubMed

Hillmann F, Novohradská S, Mattern DJ, Forberger T, Heinekamp T, Westermann M, Winckler T, Brakhage AA (2015) Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation. Environ Microbiol 17(8), 2858-2869. Details PubMed

Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J (2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), pii: e01439-14. Details PubMed Open Access

Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Brakhage AA, Valiante V (2015) Draft Genome Sequence of the Fungus Penicillium brasilianum MG11. Genome Announc 3(5), e00724-15. Details PubMed

Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA (2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10), 6058-6070. Details PubMed

Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse H-M, Brakhage AA, Hoffmeister D (2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600. Details PubMed

Kraibooj K*, Schoeler H*, Svensson C-M, Brakhage AA, Figge MT (2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally. Details PubMed Open Access

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162. Details PubMed

Mattern DJ, Schoeler H, Weber J, Novohradská S, Kraibooj K, Dahse HM, Hillmann F, Valiante V, Figge MT, Brakhage AA (2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161. Details PubMed

Mattern DJ, Valiante V, Unkles SE, Brakhage AA (2015) Synthetic Biology of Fungal Natural Products Front. Microbiol. 6, 775. (Review) Details Open Access

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details

Netzker T, Fischer J, Weber J, Mattern DJ, König CC, Valiante V, Schroeckh V, Brakhage AA (2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. Front Microbiol 6, 299. (Review) Details PubMed

Valiante V, Macheleidt J, Föge M, Brakhage AA (2015) The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. Front Microbiol 6, 325. (Review) Details PubMed

Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, de Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA (2015) Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). Antimicrob Agents Chemother 59(9), 5145-5153. Details PubMed

Bacher P, Kniemeyer O, Schönbrunn A, Sawitzki B, Assenmacher M, Rietschel E, Steinbach A, Cornely OA, Brakhage AA, Thiel A, Scheffold A (2014) Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal Immunol 7(4), 916-928. Details PubMed

Bacher P, Kniemeyer O, Teutschbein T, Thoen M, Vödisch M, Wartenberg D, Scharf DH, Koester-Eiserfunke N, Schütte M, Dübel S, Assenmacher M, Brakhage AA, Scheffold A (2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi-parameter characterization of specific conventional and regulatory CD4+ T cells. Journal of Immunology 197(7), 3332-3343. Details PubMed

Bayry J, Beaussart A, Dufrêne YF, Sharma M, Bansal K, Kniemeyer O, Aimanianda V, Brakhage AA, Kaveri SV, Kwon-Chung KJ, Latgé JP, Beauvais A (2014) Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response. Infect Immun 82(8), 3141-3153. Details PubMed

Benoit I, van den Esker MH, Patyshakuliyeva A, Mattern DJ, Blei F, Zhou M, Dijksterhuis J, Brakhage AA, Kuipers OP, de Vries RP, Kovács AT (2014) Bacillus subtilis attachment to Aspergillus niger hyphae results in mutually altered metabolism. Environ Microbiol 17(6), 2099-2113. Details PubMed

Bohnert M, Nützmann HW, Schroeckh V, Horn F, Dahse HM, Brakhage AA, Hoffmeister D (2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108. Details PubMed

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Mühlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H (2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19), 2261-2276. Details PubMed

Habel A, Scharf DH, Heinekamp T, Brakhage AA, Hertweck C (2014) Opposed Effects of Enzymatic Gliotoxin N-and S-Methylations J.Am.Chem.Soc. (136), 11674-11679. Details

Heinekamp T, Valiante V, Koester-Eiserfunke N, Brakhage AA (2014) Functional genomics to characterize opportunistic pathogens. In: Nowrousian M (ed.) The Mycota 13, pp. 321-347. Springer. ISBN: 9783642452178. Details

Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA (2014) The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus. Mol Microbiol 93(3), 539-553. Details PubMed

Horn F, Schroeckh V, Netzker T, Guthke R, Brakhage AA, Linde J (2014) Draft genome sequence of Streptomyces iranensis. Genome Announc 2(4), e00616-14. Details PubMed

Horn F, Valiante V, Guthke R, Brakhage AA (2014) Data-driven systems biology of fungal infections. In: Sullivan D, Moran GP (eds.) Human pathogenic Fungi: Molecular biology and pathogenic mechanisms Caister Academic Press, Norfolk, U.K.. ISBN: 978-1-908230-44. Details

Kroll K, Pähtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O (2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as important contributor to hypoxic survival. Eukaryot Cell 13(9), 1241-1253. Details PubMed

Lapp K, Vödisch M, Kroll K, Strassburger M, Kniemeyer O, Heinekamp T, Brakhage AA (2014) Characterisation of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and impact on virulence. Frontiers in Microbiology 5, 469. Details PubMed

Perez-Nadales E, Almeida Nogueira MF, Baldin C, Castanheira S, El Ghalid M, Grund E, Lengeler K, Marchegiani E, Mehrotra PV, Moretti M, Naik V, Oses-Ruiz M, Oskarsson T, Schäfer K, Wasserstrom L, Brakhage AA, Gow NA, Kahmann R, Lebrun MH, Perez-Martin J, Di Pietro A, Talbot NJ, Toquin V, Walther A, Wendland J (2014) Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet Biol 70C, 42-67. Details PubMed

Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM (2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8), 2221-2224. Details PubMed

Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C (2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679. Details PubMed

Scharf DH, Heinekamp T, Brakhage AA (2014) Human and plant fungal pathogens: the role of secondary metabolites. PLoS Pathog 10(1), e1003859. (Review) Details PubMed

Schroeckh V, Nützmann HW, Brakhage AA (2014) Fungal-actinomycete interactions – wakening of silent fungal secondary metabolism gene clusters via interorganismic interactions. In: Osbourn A, Goss RJ, Carter GT (eds.) Natural Products: Discourse, Diversity, and Design pp. 147-158. Wiley-Blackwell. ISBN: 978-1-118-29806. Details

Schwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M, Brakhage AA, Gabaldón T, Böcker S, Voigt K (2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial Mucorales (Mucoromycotina). PLoS Genetics 10(8), e1004496. Details PubMed Open Access

Unkles SE, Valiante V, Mattern DJ, Brakhage AA (2014) Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem Biol 21(4), 502-508. Details PubMed

Beauvais A, Bozza S, Kniemeyer O, Formosa C, Formosa C, Balloy V, Henry C, Roberson RW, Dague E, Chignard M, Brakhage AA, Romani L, Latgé JP (2013) Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus. PLoS Pathog 9(11), e1003716-e1003716. Details PubMed

Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11(1), 21-32. (Review) Details PubMed

Knop K, Pavlov GM, Rudolph T, Martin K, Pretzel D, Jahn BO, Scharf DH, Brakhage AA, Makarov V, Möllmann U, Schacher FH, Schubert US (2013) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide Soft Matter 3(9), 715-726. Details

Knop K, Pretzel D, Urbanek A, Rudolph T, Scharf DH, Schallon A, Wagner M, Schubert S, Kiehntopf M, Brakhage AA, Schacher FH, Schubert US (2013) Star-shaped drug carriers for doxorubicin with POEGMA and POEtOxMA brush-like shells: a structural, physical, and biological comparison. Biomacromolecules 14(8), 2536-2548. Details PubMed

König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. Details PubMed

Muszkieta L, Beauvais A, Pähtz V, Gibbons JG, Anton Leberre V, Beau R, Shibuya K, Rokas A, Francois JM, Kniemeyer O, Brakhage AA, Latgé JP (2013) Investigation of Aspergillus fumigatus biofilm formation by various Front Microbiol 4, 13-13. Details PubMed

Nützmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA (2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109. Details PubMed

Scharf DH, Brakhage AA (2013) Engineering fungal secondary metabolism: a roadmap to novel compounds. J Biotechnol 163(2), 179-183. (Review) Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C (2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095. Details PubMed

Shopova I, Bruns S, Thywissen A, Kniemeyer O, Brakhage AA, Hillmann F (2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4, 141. Details PubMed

Werner W, Herold M, Ruffert K, Merkle K, Brakhage A, Leoni L, Cheson BD (2013) Developmental history: bendamustine yesterday, today, tomorrow. Onkologie 36 Suppl 1, 2-10. Details PubMed

Gil Girol C, Fisch KM, Heinekamp T, Günther S, Hüttel W, Piel J, Brakhage AA, Müller M (2012) Regio- and stereoselective oxidative phenol coupling in Aspergillus niger. Angew Chem Int Ed Engl 51(39), 9788-9791. Details PubMed

Heddergott C, Bruns S, Nietzsche S, Leonhardt I, Kurzai O, Kniemeyer O, Brakhage AA (2012) The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells. Eukaryot Cell 11(5), 673-682. Details PubMed

Heinekamp T, Thywißen A, Macheleidt J, Keller S, Valiante V, Brakhage AA (2012) Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol 3, 440. Details PubMed

Horn F, Heinekamp T, Kniemeyer O, Pollmächer J, Valiante V, Brakhage AA (2012) Systems biology of fungal infection. Front Microbiol 3, 108. Details PubMed Open Access

Huber EM, Scharf DH, Hortschansky P, Groll M, Brakhage AA (2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10), 1757-1768. Details PubMed

Linde J, Hortschansky P, Fazius E, Brakhage AA, Guthke R, Haas H (2012) Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6, 6. Details PubMed

Martinez DA, Oliver BG, Gräser Y, Goldberg JM, Li W, Martinez-Rossi NM, Monod M, Shelest E, Barton RC, Birch E, Brakhage AA, Chen Z, Gurr SJ, Heiman D, Heitman J, Kosti I, Rossi A, Saif S, Samalova M, Saunders CW, Shea T, Summerbell RC, Xu J, Young S, Zeng Q, Birren BW, Cuomo CA, White TC (2012) Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio 3(5), e00259. Details PubMed

Müller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC Genomics 13, 519. Details PubMed

Nützmann HW, Schroeckh V, Brakhage AA (2012) Regulatory cross talk and microbial induction of fungal secondary metabolite gene clusters. Methods Enzymol 517, 325-341. Details PubMed

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068. Details PubMed

Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C (2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472. Details PubMed

Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM (2012) Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158(Pt 6), 1634-1644. Details PubMed

Wartenberg D, Vödisch M, Kniemeyer O, Albrecht-Eckardt D, Scherlach K, Winkler R, Weide M, Brakhage AA (2012) Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans - The role of a putative dehydrin. J Proteomics 75(13), 4038-4049. Details PubMed

Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R (2011) On the way toward systems biology of Aspergillus fumigatus infection. Int J Med Microbiol 301(5), 453-459. Details PubMed

Brakhage AA, Gross U, Morschhäuser J (2011) Pathobiology of human-pathogenic fungi. Int J Med Microbiol 301(5), 367-367. Details PubMed

Brakhage AA, Schroeckh V (2011) Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol 48(1), 15-22. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Hasenberg M, Behnsen J, Krappmann S, Brakhage AA, Gunzer M (2011) Phagocyte responses towards Aspergillus fumigatus. Int J Med Microbiol 301(5), 436-444. Details PubMed

Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53. Details PubMed

Keller S, Macheleidt J, Scherlach K, Schmaler-Ripcke J, Jacobsen ID, Heinekamp T, Brakhage AA (2011) Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence. PLoS One 6(10), e26604. Details PubMed

Kniemeyer O, Schmidt AD, Vödisch M, Wartenberg D, Brakhage AA (2011) Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics. Int J Med Microbiol 301(5), 368-377. Details PubMed

Mech F*, Thywissen A*, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLOS ONE 6(5), e19591, *authors contributed equally. Details PubMed Open Access

Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J, Hertweck C, Strauss J, Brakhage AA (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287. Details PubMed

Priebe S, Linde J, Albrecht D, Guthke R, Brakhage AA (2011) FungiFun: A web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol 48(4), 353-358. Details PubMed

Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325. Details PubMed

Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42), 9843-9847. Details PubMed

Scherlach K, Sarkar A, Schroeckh V, Dahse HM, Roth M, Brakhage AA, Horn U, Hertweck C (2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839. Details PubMed

Thywißen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA (2011) Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway. Front Microbiol / Fungi and their interactions 2, 96. Details PubMed

Vödisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O (2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5), 2508-2524. Details PubMed

Volling K, Thywissen A, Brakhage AA, Saluz HP (2011) Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8), 1130-1148. Details PubMed

Wartenberg D, Lapp K, Jacobsen ID, Dahse HM, Kniemeyer O, Heinekamp T, Brakhage AA (2011) Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol 301(7), 602-611. Details PubMed

Albrecht D, Guthke R, Brakhage AA, Kniemeyer O (2010) Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics 11, 32. Details PubMed

Albrecht D, Kniemeyer O, Brakhage AA, Guthke R (2010) Missing values in gel-based proteomics. Proteomics 10(6), 1202-1211. Details PubMed

Behnsen J, Lessing F, Schindler S, Wartenberg D, Jacobsen ID, Thoen M, Zipfel PF, Brakhage AA (2010) Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun 78(8), 3585-3594. Details PubMed

Bergmann S, Funk AN, Scherlach K, Schroeckh V, Shelest E, Horn U, Hertweck C, Brakhage AA (2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24), 8143-8149. Details PubMed Open Access PDF Supplement

Brakhage AA, Bruns S, Thywissen A, Zipfel PF, Behnsen J (2010) Interaction of phagocytes with filamentous fungi. Curr Opin Microbiol 13(4), 409-415. Details PubMed

Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywissen A, Jeron A, Latgé JP, Brakhage AA, Gunzer M (2010) Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog 6(4), e1000873. Details PubMed

Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Müller FM (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107. Details PubMed

Gehrke A, Heinekamp T, Jacobsen ID, Brakhage AA (2010) Heptahelical receptors GprC and GprD of Aspergillus fumigatus are essential regulators of colony growth, hyphal morphogenesis, and virulence. Appl Environ Microbiol 76(12), 3989-3998. Details PubMed

Mouyna I, Kniemeyer O, Jank T, Loussert C, Mellado E, Aimanianda V, Beauvais A, Wartenberg D, Sarfati J, Bayry J, Prévost MC, Brakhage AA, Strahl S, Huerre M, Latgé JP (2010) Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability. Mol Microbiol 76(5), 1205-1221. Details PubMed

Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29), 10136-10141. Details PubMed

Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jöchl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H (2010) HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6(9), e1001124-e1001124. Details PubMed

Teutschbein J, Albrecht D, Pötsch M, Guthke R, Aimanianda V, Clavaud C, Latgé JP, Brakhage AA, Kniemeyer O (2010) Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res 9(7), 3427-3442. Details PubMed

Thön M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA (2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4), 1098-1113. Details PubMed

Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, Elluru SR, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP (2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460(7259), 1117-1121. Details PubMed

Brakhage AA, Thön M, Spröte P, Scharf DH, Al-Abdallah Q, Wolke SM, Hortschansky P (2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70(15-16), 1801-1811. Details PubMed

Kniemeyer O, Lessing F, Brakhage AA (2009) Proteome analysis for pathogenicity and new diagnostic markers for Aspergillus fumigatus. Med Mycol 47 Suppl 1, S248-S254. Details PubMed

Rispail N, Soanes DM, Ant C, Czajkowski R, Grünler A, Huguet R, Perez-Nadales E, Poli A, Sartorel E, Valiante V, Yang M, Beffa R, Brakhage AA, Gow NA, Kahmann R, Lebrun MH, Lenasi H, Perez-Martin J, Talbot NJ, Wendland J, Di Pietro A (2009) Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genet Biol 46(4), 287-298. Details PubMed

Schmaler-Ripcke J, Sugareva V, Gebhardt P, Winkler R, Kniemeyer O, Heinekamp T, Brakhage AA (2009) Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol 75(2), 493-503. Details PubMed

Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34), 14558-14563. Details PubMed

Spröte P, Brakhage AA, Hynes MJ (2009) Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans. Eukaryot Cell 8(3), 421-423. Details PubMed

Valiante V, Jain R, Heinekamp T, Brakhage AA (2009) The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet Biol 46(12), 909-918. Details PubMed

Vödisch M, Albrecht D, Lessing F, Schmidt AD, Winkler R, Guthke R, Brakhage AA, Kniemeyer O (2009) Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics 9(5), 1407-1415. Details PubMed

Brakhage AA, Schuemann J, Bergmann S, Scherlach K, Schroeckh V, Hertweck C (2008) Activation of fungal silent gene clusters: a new avenue to drug discovery. Prog Drug Res 66, 1, 3-1,12. Details PubMed

Erhard M, Hipler UC, Burmester A, Brakhage AA, Wöstemeyer J (2008) Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry. Exp Dermatol 17(4), 356-361. Details PubMed

Grosse C, Heinekamp T, Kniemeyer O, Gehrke A, Brakhage AA (2008) Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus. Appl Environ Microbiol 74(15), 4923-4933. Details PubMed

Ibrahim-Granet O, Dubourdeau M, Latgé JP, Ave P, Huerre M, Brakhage AA, Brock M (2008) Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol 10(1), 134-148. Details PubMed

Mota Júnior AO, Malavazi I, Soriani FM, Heinekamp T, Jacobsen I, Brakhage AA, Savoldi M, Goldman MH, da Silva Ferreira ME, Goldman GH (2008) Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA. Mol Genet Genomics 280(6), 483-495. Details PubMed

Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H (2008) SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1), 27-43. Details PubMed

Spröte P, Hynes MJ, Hortschansky P, Shelest E, Scharf DH, Wolke SM, Brakhage AA (2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70(2), 445-461. Details PubMed

Valiante V, Heinekamp T, Jain R, Härtl A, Brakhage AA (2008) The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal Genet Biol 45(5), 618-627. Details PubMed

Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M (2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 3(2), e13. Details PubMed

Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4), 213-217. Details PubMed

da Silva Ferreira ME, Heinekamp T, Härtl A, Brakhage AA, Semighini CP, Harris SD, Savoldi M, de Gouvêa PF, de Souza Goldman MH, Goldman GH (2007) Functional characterization of the Aspergillus fumigatus calcineurin. Fungal Genet Biol 44(3), 219-230. Details PubMed

Guthke R, Kniemeyer O, Albrecht D, Brakhage AA, Moeller U (2007) Discovery of gene regulatory networks in Aspergillus fumigatus Lect Notes Bioinf 4366, Details

Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thön M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H (2007) Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13), 3157-3168. Details PubMed

Lessing F, Kniemeyer O, Wozniok I, Loeffler J, Kurzai O, Haertl A, Brakhage AA (2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12), 2290-2302. Details PubMed

Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F (2007) Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 9(2), 368-381. Details PubMed

Schöbel F, Ibrahim-Granet O, Avé P, Latgé JP, Brakhage AA, Brock M (2007) Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. Infect Immun 75(3), 1237-1244. Details PubMed

Spröte P, Brakhage AA (2007) The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis. Arch Microbiol 188(1), 69-79. Details PubMed

Thön M, Al-Abdallah Q, Hortschansky P, Brakhage AA (2007) The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response. J Biol Chem 282(37), 27259-27269. Details PubMed

Volling K, Brakhage AA, Saluz HP (2007) Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2), 250-254. Details PubMed

da Silva Ferreira ME, Kress MR, Savoldi M, Goldman MH, Härtl A, Heinekamp T, Brakhage AA, Goldman GH (2006) The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5(1), 207-211. Details PubMed

da Silva Ferreira ME, Malavazi I, Savoldi M, Brakhage AA, Goldman MH, Kim HS, Nierman WC, Goldman GH (2006) Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Curr Genet 50(1), 32-44. Details PubMed

Ebel F, Schwienbacher M, Beyer J, Heesemann J, Brakhage AA, Brock M (2006) Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development. Fungal Genet Biol 43(7), 476-489. Details PubMed

Herrmann M, Spröte P, Brakhage AA (2006) Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. Appl Environ Microbiol 72(4), 2957-2970. Details PubMed

Kniemeyer O, Lessing F, Scheibner O, Hertweck C, Brakhage AA (2006) Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet 49(3), 178-189. Details PubMed

Kupfahl C, Heinekamp T, Geginat G, Ruppert T, Härtl A, Hof H, Brakhage AA (2006) Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol 62(1), 292-302. Details PubMed

Sugareva V, Härtl A, Brock M, Hübner K, Rohde M, Heinekamp T, Brakhage AA (2006) Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus. Arch Microbiol 186(5), 345-355. Details PubMed