Marc Thilo Figge

Prof. Dr. Marc Thilo Figge

Angewandte Systembiologie · Abteilungsleiter

Telefon: +49 3641 532-1416 Telefax: +49 3641 532-2416 E-Mail: thilo.figge@leibniz-hki.de

Forschungsschwerpunkte
  • Wirt-Pathogen Interaktion bei humanpathogenen Pilzen
  • Automatisierte Verarbeitung mikroskopischer Bilddaten
  • Raumzeitliche Computersimulationen agentenbasierter Infektionsmodelle
Curriculum vitae

Wissenschaftlicher Werdegang

seit 2011  Professor (W2) für Angewandte Systembiologie, Friedrich-Schiller-Universität Jena
2005-2010 Junior Fellow in Theoretische Immunologie am Frankfurt Institute for Advanced Studies (FIAS) der Goethe Universität Frankfurt
2001-2005 Wissenschaftlicher Mitarbeiter in Computerphysik an der Universität Groningen (NL)
2000 Dr. rer. nat. in Physik an der Universität Groningen (NL)
1995 Diplom in Physik an der Universität Dortmund

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

seit 2011 Adjunct Fellow am Frankfurt Institute for Advanced Studies (FIAS) der Goethe Universität Frankfurt
seit 2011 Mitglied in den Fakultäten der „Jena School for Microbial Communication“ (JSMC) und „International Leibniz Research School“ (ILRS)
Publikationen

Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT (2017) Migration and Interaction Tracking for Quantitative Analysis of Phagocyte-Pathogen Confrontation Assays. Medical Image Analysis 36, 172-183. Details PubMed Open Access PDF

Cseresnyes Z*, Kraibooj K*, Figge MT, *authors contributed equally (2017) Hessian-based quantitative image analysis of host- pathogen confrontation assays. Cytometry A [Accepted] Details

Dudeck J*, Medyukhina A*, Froebel J, Svensson C-M, Kotrba J, Gerlach M, Gradtke A-C, Schröder B, Speier S, Figge MT**, and Dudeck A**; *authors contributed equally; ** corresponding authors, authors contributed equally (2017) Mast cells acquire MHCII from dendritic cells during skin inflammation. The Journal of Experimental Medicine [Accepted] Details

Figge MT (2017) Systems Biology of Infection In: NOVA ACTA LEOPOLDINA (ed.) Crossing Boundaries in Science Documentation of the Workshop of the German National Academy of Sciences Leopoldina, Weimar, 06/30/2016-07/02/2016, 419, pp. 45-51.Wissenschaftliche Verlagsgesellschaft Stuttgart, Halle (Saale). ISBN: 978-3-8047-3758. Details Open Access PDF

Hoffmann B*, Svensson CM*, Straßburger M, Gebser B, Irmler IM, Kamradt T, Saluz HP, Figge MT, *authors contributed equally (2017) Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging. Sci Rep 7, 2217. Details Open Access PDF

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M (2017) Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy. Journal of the American Society of Nephrology 28(2), 452-459. Details PubMed

Meinel C, Spartà G, Dahse H-M, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2017) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. The Journal of Infectious Diseases (jix305), Details

Svensson C-M, Bondoc K G, Pohnert G, Figge MT (2017) Segmentation of clusters by template rotation expectation maximization. Computer Vision and Image Understanding 152, 64-72. Details

Svensson C-M, Medyukhina A, Belyaev I, Al-Zaben N, Figge MT (2017) Untangling cell tracks: quantifying cell migration by time lapse image data analysis. Cytometry A [Accepted] Details

Svensson CM*, Hoffmann B*, Irmler I, Straßburger M, Figge M, Saluz HP, *authors contributed equally (2017) Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Sci Rep 7, 44434. Details PubMed Open Access PDF Supplement

Buhlmann D*, Eberhardt HU*, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C *authors contributed equally (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. Journal of Immunology 197(2), 620-629. Details PubMed

Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Nature Scientific Reports 6, 27807. Details PubMed Open Access PDF Supplement

Brandes S, Mokhtari Z, Essig F, Hünniger K, Kurzai O, Figge MT (2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Medical Image Analysis 20(1), 34-51. Details PubMed

Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O (2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276. Details PubMed

Essig F, Hünniger K, Dietrich S, Figge MT, Kurzai O (2015) Human neutrophils dump Candida glabrata after intracellular killing. Fungal Genetics and Biology 84, 37-40. Details PubMed

Figge MT, (2015) Image-based Systems Biology: what you get is more than you can see. G.I.T. Laboratory Journal Europe 19, 13-15. Details Open Access

Figge MT, Murphy RF (2015) Image-based Systems Biology. Cytometry A 87(6), 459-461. Details PubMed

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo R, Riedemann N, Kurzai O (2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210. Details PubMed

Kraibooj K*, Schoeler H*, Svensson C-M, Brakhage AA, Figge MT (2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally. Details PubMed Open Access

Lehnert T*, Timme S*, Pollmächer J, Hünniger K, Kurzai O, Figge MT (2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally. Details PubMed Open Access

Mahler L, Tovar M, Weber T, Brandes S, Rudolph MM, Ehgartner J, Mayr T, Figge MT, Roth M, Zang E (2015) Enhanced and homogeneous oxygen availability during incubation of microfluidic droplets. RSC Advances 5, 101871-101878. Details Open Access PDF Supplement

Mattern DJ, Schoeler H, Weber J, Novohradská S, Kraibooj K, Dahse HM, Hillmann F, Valiante V, Figge MT, Brakhage AA (2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161. Details PubMed

Medyukhina A, Timme S, Mokhtari Z, Figge MT (2015) Image-based Systems Biology of Infection. Cytometry A 87(6), 462-470. Details PubMed

Mokhtari Z*, Mech F*, Zehentmeier S, Hauser AE, Figge MT (2015) Quantitative image analysis of cell colocalization in murine bone marrow. Cytometry A 87(6), 503-512, *authors contributed equally. Details PubMed

Pollmächer J, Figge MT (2015) Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli. Frontiers in Microbiology 6(503), Details PubMed Open Access

Svensson C-M, Hübler R, Figge MT (2015) Automated classification of circulating tumor cells and the impact of inter-observer variability on classifier training and performance. Journal of Immunology Research 2015(Article ID 573165), 9. Details PubMed Open Access

Hünniger K*, Lehnert T*, Bieber K, Martin R, Figge MT⁺, Kurzai O⁺ (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLoS Comput Biol 10(2), e1003479, */⁺authors contributed equally. Details PubMed Open Access

Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T (2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155. Details PubMed Open Access

Kraibooj K*, Park HR*, Dahse HM, Skerka C, Voigt K⁺, Figge MT⁺ (2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally. Details PubMed Open Access

Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed

Pollmächer J, Figge MT (2014) Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection. PLOS ONE 9(10), e111630. Details PubMed Open Access

Svensson C-M, Krusekopf S, Lücke J, Figge MT (2014) Automated detection of circulating tumor cells with naive Bayesian classifiers. Cytometry A 85(6), 501-511. Details PubMed

Coelho FM, Natale D, Soriano SF, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes HG, Junt T, Sailer AW, Ludewig B, Sharpe J, Figge MT, Stein JV (2013) Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 121(20), 4101-4109. Details PubMed

Figge MT, Osiewacz HD, Reichert AS (2013) Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics? Bioessays 35(4), 314-322. Details PubMed

Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M, Figge MT (2013) Automated characterization and parameter-free classification of cell tracks based on local migration behavior. PLOS ONE 8(12), e80808. Details PubMed Open Access

Zang E*, Brandes S*, Tovar M, Martin K, Mech F, Horbert P, Henkel T, Figge MT, Roth M (2013) Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets. Lab Chip 13(18), 3707-3713, *authors contributed equally. Details PubMed Open Access

Zhang Y, Meyer-Hermann M, George LA, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KM (2013) Germinal center B cells govern their own fate via antibody feedback. J Exp Med 210(3), 457-464. Details PubMed Open Access

Figge MT, Reichert AS, Meyer-Hermann M, Osiewacz HD (2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLoS Comput Biol 8(6), e1002576. Details PubMed Open Access

Guthke R, Linde J, Mech F, Figge MT (2012) Systems biology of microbial infection. Front Microbiol 3, 328. Details PubMed Open Access

Mech F, Figge MT (2012) Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence. In: Highlight Papers of the German Conference on Bioinformatics 2012 German Conference on Bioinformatics, Jena, GCB. Details PDF

Tokarski C, Hummert S, Mech F, Figge MT, Germerodt S, Schroeter A, Schuster S (2012) Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi. Front Microbiol 3, 129. Details PubMed Open Access

Figge MT, Meyer-Hermann M (2011) Modelling Intravital Two-Photon Data of Lymphocyte Migration and Interaction In: Molina-París C, Lythe G (eds.) Mathematical Models and Immune Cell Biology pp. 121-139. Springer, Heidelberg. ISBN: 978-1-4419-7724. Details

Mech F*, Thywissen A*, Guthke R, Brakhage AA, Figge MT (2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLOS ONE 6(5), e19591, *authors contributed equally. Details PubMed Open Access

Fatehi H, Meyer-Hermann M, Figge MT (2010) Modelling cellular aggregation induced by chemotaxis and phototaxis. Math Med Biol 27(4), 373-384. Details PubMed

Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH (2010) Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation. Immunity 33(1), 84-95. Details PubMed Open Access

Figge MT (2009) Optimization of immunoglobulin substitution therapy by a stochastic immune response model. PLOS ONE 4(5), e5685. Details PubMed Open Access

Figge MT, Meyer-Hermann M (2009) Modeling receptor-ligand binding kinetics in immunological synapse formation. The European Physical Journal D 51(1), 153-160. Details

Meyer-Hermann M, Figge MT, Straub RH (2009) Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach. Arthritis Rheum 60(9), 2585-2594. Details PubMed Open Access

Meyer-Hermann M, Figge MT, Toellner KM (2009) Germinal centres seen through the mathematical eye: B-cell models on the catwalk. Trends Immunol 30(4), 157-164. Details PubMed

Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner KM, Meyer-Hermann M (2008) Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med 205(13), 3019-3029. Details PubMed Open Access

Figge MT, Meyer-Hermann M (2006) Geometrically repatterned immunological synapses uncover formation mechanisms. PLoS Comput Biol 2(11), e171. Details PubMed Open Access

Michielsen K, Figge MT, De Raedt H, De Hossen JTM (2004) Molecular dynamics simulation of nanoindentation In: Computer simulation studies incondensed-matter physics XVI pp. 250-255.Springer-Verlag, Berlin Heidelberg. ISBN: 978-3-642-63923. Details

De Raedt H, Kole JS, Michielsen K, Figge MT (2003) Unified framework for numerical methods to solve the time-dependent Maxwell equations. Computer Physics Communication 156, 43-61. Details PDF

De Raedt H, Michielsen K, Kole JS, Figge MT (2003) Chebyshev method to solve the time-dependent Maxwell equations. In: Computer simulation studies in condensed-matter physics XV, pp. 211-215.Springer-Verlag Berlin Heidelberg. Details

De Raedt H, Michielsen K, Kole JS, Figge MT (2003) One-step finite-difference time-domain algorithm to solve the Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 67(5 Pt 2), 056706. Details PubMed

De Raedt H, Michielsen K, Kole JS, Figge MT (2003) Solving the Maxwell equations by the Chebyshev method: a one-step finite-difference time-domain algorithm. IEEE Transactions on Antennas and Propagation 51, 3155-3160. Details PDF

Figge MT, Michielsen K, De Raedt H, De Hosson JTM, van der Giessen E (2003) Molecular dynamics simulation of dislocation dynamics during nanoindentation. In: Advances in Computational & Experimental Engeneering & Sciences International Conference ICCES 2003, Tech Science Press. Details

Kole JS, Figge MT, De Raedt H (2003) Solving the time-dependent Maxwell equations by unconditionally stable algorithms. In: Computer simulation studies in condensed-matter physics XV pp. 205-210.Springer-Verlag Berlin Heidelberg. Details

Figge MT (2002) Statistical model for receptor-ligand binding thermodynamics. Phys Rev E Stat Nonlin Soft Matter Phys 66(6 Pt 1), 061901. Details PubMed

Figge MT, Mostovoy M, Knoester J (2002) Peierls instability due to the interaction of electrons with both acoustic and optical phonons in metallic carbon nanotubes. Physical Review B 65(12), 125416. Details

Kole JS, Figge MT, and De Raedt H (2002) New unconditionally stable algorithms to solve the time-dependent Maxwell equations. Springer Verlag Lecture Notes in Computer Science (LNCS) 2329, 803. Details

Kole JS, Figge MT, De Raedt H (2002) Higher-order unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 65(6 Pt 2), 066705. Details PubMed

Figge MT, Mostovoy M, Knoester J (2001) Peierls transition with acoustic phonons and solitwistons in carbon nanotubes. Phys Rev Lett 86(20), 4572-4575. Details PubMed

Kole JS, Figge MT, De Raedt H (2001) Unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 64(6 Pt 2), 066705. Details PubMed

Figge MT (2000) Disorder and interchain interactions in Peierls systems. In: PhD thesis, University of Groningen. ISBN: ISBN 90-367-127. Details PDF

Figge MT, Mostovoy M, Knoester J (1999) Disorder-induced neutral solitons in degenerate ground state polymers. Synthetic Metals 101(1-3), 388-389. Details

Figge MT, Mostovoy M, Knoester J (1999) Magnetic susceptibility due to disorder-induced neutral solitons in interacting polymer chains. Physical Review B 59(21), 13882-13891. Details Open Access PDF

Mostovoy M, Figge MT, Knoester J (1998) Density of neutral solitons in weakly disordered Peierls chains. Physical Review B 57(5), 2861-2871. Details Open Access PDF

Mostovoy M, Figge MT, Knoester J (1998) Critical temperature and density of spin flips in the anisotropic random-field Ising model. Physical Review B 58(5), 2626-2634. Details Open Access PDF

Mostovoy M, Figge MT, Knoester J (1997) Disorder-induced solitons in conjugated polymers. Europhysics Letters 38(9), 687-692. Details