Welcome

Microbial natural products serving as mediators of biological communication are essential for our lives. They do, however, play an ambivalent role: on the one hand, they contribute to the generation of many infectious diseases; on the other hand, they belong to the most important sources provided in drugs such as antibiotics. 

We investigate the communication between micro-organisms to be able to make use of the acquired know-how to develop innovative components for the diagnosis and therapy of diseases. By means of implementing those research results and the derived models thereof, we make a contribution to the development of the systems biology of an infection.

Dr. Slavena Vylkova (Quelle: Jan-Peter Kasper/FSU)

How fungi turn into dangerous pathogens // 15.09.2016

New research group „Host Fungal Interfaces“ starts in October more…

Healthy habits mean healthy eyes // 19.08.2016

Scientists of the NRZMyk join the CDC's Contact Lense Health week and inform about fungal keratitis more…

Events

30.09.2016 - 30.09.2016 // HKI-Center for Systems Biology of Infection

Image-based Systems Biology

04.10.2016 - 07.10.2016 // Friedrich Schiller University Jena

International Study Group for Systems Biology (ISGSB) meeting

Publications

Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR

Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature

Klapper M, Götze S, Barnett R, Willing K, Stallforth P

Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl

Jobs