Welcome

Microbial natural products serving as mediators of biological communication are essential for our lives. They do, however, play an ambivalent role: on the one hand, they contribute to the generation of many infectious diseases; on the other hand, they belong to the most important sources provided in drugs such as antibiotics. 

We investigate the communication between micro-organisms to be able to make use of the acquired know-how to develop innovative components for the diagnosis and therapy of diseases. By means of implementing those research results and the derived models thereof, we make a contribution to the development of the systems biology of an infection.

March for Science // 28.03.2017

HKI supports the "March for Science" on 22. April 2017 in Jena more…

Plant leaf under the new laboratory setup.

Up and Down for Chemical Visibility // 17.03.2017

Jena scientists extend mass spectrometric imaging to non-flat biological surfaces. more…

Fresh funds for new research // 02.03.2017

Hajo Kries receives fellowship of the Daimler and Benz Foundation more…

Events

05.04.2017 // 10:00 Uhr // IAAC, Humboldtstr. 8

Philip Wojtas:
Totalsynthese von Nosiheptid

10.04.2017 - 11.04.2017 // München

Leibniz Meeting on Bioactive Compounds 2017

Publications

Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR

Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature

Klapper M, Götze S, Barnett R, Willing K, Stallforth P

Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl

Jobs