Microbial natural products serving as mediators of biological communication are essential for our lives. They do, however, play an ambivalent role: on the one hand, they contribute to the generation of many infectious diseases; on the other hand, they belong to the most important sources provided in drugs such as antibiotics. 

We investigate the communication between micro-organisms to be able to make use of the acquired know-how to develop innovative components for the diagnosis and therapy of diseases. By means of implementing those research results and the derived models thereof, we make a contribution to the development of the systems biology of an infection.

Balance of the Microverse // 22.02.2018

Full proposal for Cluster of Excellence with participation of the HKI submitted more…

Leibniz Trainee Award 2017 for HKI employee // 01.12.2017

Biologielaborantin Dorothee Eckhardt freut sich über die Auszeichnung more…

Welcome to the HKI! // 10.10.2017

Miriam Rosenbaum takes over as head of the Bio Pilot Plant more…


15.03.2018 // 18:00 - 19:00 Uhr // Lecture hall Erbertstraße

Prof. Dr. Wilhelm Boland:
Chemische Ökologie – Wissen fur die Zukunft

19.03.2018 - 22.03.2018 // Friedrich Schiller University Jena, Carl-Zeiss-Str. 3

MiCom 2018


March for Science


Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR

Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature

Klapper M, Götze S, Barnett R, Willing K, Stallforth P

Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl