Microbial natural products serving as mediators of biological communication are essential for our lives. They do, however, play an ambivalent role: on the one hand, they contribute to the generation of many infectious diseases; on the other hand, they belong to the most important sources provided in drugs such as antibiotics. 

We investigate the communication between micro-organisms to be able to make use of the acquired know-how to develop innovative components for the diagnosis and therapy of diseases. By means of implementing those research results and the derived models thereof, we make a contribution to the development of the systems biology of an infection.

Award-winning times for the HKI // 21.09.2015

49th Scientific Conference of the German speaking Mycological Society (DMykG) e. V. and 1st International Symposium of the CRC/Transregio FungiNet more…

Mycologists meet in Jena // 15.09.2015

Joint Conference of DMykG and the Collaborative Research Center FungiNet begins on Wednesday more…


13.10.2015 - 13.10.2015 // 17:15 Uhr // SR Robert Koch / Louis Pasteur, HKI-Center for Systems Biology of Infection

Dr. Falko Hochgräfe:
PTMomics in Host-Pathogen-Interactions


Schwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M, Brakhage AA, Gabaldón T, Böcker S, Voigt K

Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial Mucorales (Mucoromycotina). PLoS Genetics