Microbial natural products serving as mediators of biological communication are essential for our lives. They do, however, play an ambivalent role: on the one hand, they contribute to the generation of many infectious diseases; on the other hand, they belong to the most important sources provided in drugs such as antibiotics. 

We investigate the communication between micro-organisms to be able to make use of the acquired know-how to develop innovative components for the diagnosis and therapy of diseases. By means of implementing those research results and the derived models thereof, we make a contribution to the development of the systems biology of an infection.

From San Diego to Jena // 21.02.2017

Christin Reimer receives award for best Master thesis from BTU Cottbus-Senftenberg more…

Gianni Panagiotou

Welcome to HKI! // 04.01.2017

Gianni Panagiotou follows Reinhard Guthke as head of the research group Systems Biology and Bioinformatics more…

medac research award 2016 // 08.11.2016

Award for novel yeast toxin and predatory ameba more…

Dr. Slavena Vylkova (Quelle: Jan-Peter Kasper/FSU)

How fungi turn into dangerous pathogens // 15.09.2016

New research group „Host Fungal Interfaces“ starts in October more…


Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR

Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature

Klapper M, Götze S, Barnett R, Willing K, Stallforth P

Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl