Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.

Herold K, Gollmick FA, Groth I, Roth M, Menzel KD, Möllmann U, Gräfe U, Hertweck C (2005) Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Chemistry 11(19), 5523-5530. PubMed

Abstract

Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.

Involved Units and Groups
HKI-Authors
Identifier

PMID: 15940739