Hajo Kries

Dr. Hajo Kries

Biosynthetisches Design von Naturstoffen · Leitung

Telefon: +49 3641 532 1735 Telefax: +49 3641 532 2735 E-Mail: hajo.kries@leibniz-hki.de

Curriculum vitae

Wissenschaftlicher Werdegang

seit 2016 Nachwuchsgruppenleiter, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie (Hans-Knöll-Institut), Jena
2014-2016 Postdoc, John Innes Centre, Norwich (UK), bei Prof. Sarah E. O'Connor
2009-2014 Doktorarbeit "Tailor-made biocatalysts by enzyme design, redesign, and directed evolution" an der ETH Zürich bei Prof. Donald Hilvert
2007-2009 MSc in Chemie, ETH Zürich
2006-2007 BSc in Biochemie, Universität Genf
2003-2006 Studium der Biochemie, Universität Jena
2002 Abitur am Gymnasium Heide-Ost

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

2019 Sachkostenbeihilfe des FCI
2017-2019 Stipendium der Daimler und Benz Stiftung
2015-2016 Marie Skłodowska-Curie Stipendium (H2020), Projekt 658155
2015 Friedrich-Weygand-Preis, verliehen vom Max-Bergmann-Kreis
2015 Medaille der ETH für die Doktorarbeit
2014-2015 Early Postdoc.Mobility Stipendium des Schweizer Nationalfonds (SNF)
2011-2014 Promotionsstipendium des Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI)
2010-2012 Promotionsstipendium der Studienstiftung des deutschen Volkes
2008-2009 Oskar Jeger Stipendium für die Masterarbeit (ETH Zürich)
2008 Novartis Masterstipendium
2007-2009 DAAD Auslandsstipendium
2005-2009 Stipendium der Studienstiftung des deutschen Volkes
Publikationen

Bunzel HA, Kries H, Marchetti L, Zeymer C, Mittl P, Mulholland AJ, Hilvert D (2019) Emergence of a negative activation heat capacity during evolution of a designed enzyme. Journal of the American Chemical Society 141(30), 11745-11748. Details PubMed PDF

Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, García-Altares M, Willing K, Günther M, Stallforth P (2019) Structure Elucidation of the Syringafactin Lipopeptides Provides Insight in the Evolution of Nonribosomal Peptide Synthetases Chem Sci [Accepted] Details

Huang HM, Kries H (2019) Unleashing the Potential of Ribosomal and Nonribosomal Peptide Biosynthesis. Biochemistry 58(2), 73-74. (Review) Details PubMed PDF

Lichman B, O'Connor SE, Kries H (2019) Biocatalytic strategies towards [4+2] cycloadditions. Chem. Eur. J. 25(28), 6864-6877. (Review) Details PubMed PDF

Stanišić A, Hüsken A, Kries, H (2019) HAMA: A multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes. Chem Sci 10, 10395-10399. Details Open Access PDF Supplement

Stanišić A, Kries H (2019) Adenylation domains in nonribosomal peptide engineering. ChemBioChem 20(11), 1347-1356. (Review) Details PubMed PDF

Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D (2018) Nonribosomal biosynthesis of backbone-modified peptides Nat Chem 10(3), 282-287. Details PubMed PDF

Kries H, Kellner F, Kamileen O, O'Connor SE (2017) Inverted stereocontrol of iridoid synthase in snapdragon J Biol Chem 292(35), 14659-14667. Details PubMed Open Access

Alagna F, Geu-Flores F, Kries H, Panara F, Baldoni L, O'Connor SE, Osbourn A (2016) Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits. J Biol Chem 291(11), 5542-5554. Details PubMed

Kries H (2016) Biosynthetic engineering of nonribosomal peptide synthetases. J Pept Sci 22(9), 564-570. Details PubMed

Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE (2016) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat Chem Biol 12(1), 6-8. Details PubMed

Kries H, O'Connor SE (2016) Biocatalysts from alkaloid producing plants. Curr Opin Chem Biol 31, 22-30. (Review) Details PubMed

Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC (2016) Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract. Adv Mater 28(7), 1455-1460. Details PubMed

Kries H, Niquille DL, Hilvert D (2015) A subdomain swap strategy for reengineering nonribosomal peptides. Chem Biol 22(5), 640-648. Details PubMed

Kries H, Wachtel R, Pabst A, Wanner B, Niquille D, Hilvert D (2014) Reprogramming nonribosomal peptide synthetases for "clickable" amino acids Angew Chem Int Ed Engl 53(38), 10105-10108. Details PubMed

von Sperber C, Kries H, Tamburini F, Bernasconi SM, Frossard E (2014) The effect of phosphomonoesterases on the oxygen isotope composition of phosphate Geochim Cosmochim Acta 125, 519-527. Details

Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D (2013) Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature 503(7476), 418-421. Details PubMed

Kries H, Blomberg R, Hilvert D (2013) De novo enzymes by computational design. Curr Opin Chem Biol 17(2), 221-228. Details PubMed

Kries H, Hilvert D (2011) Tailor-made peptide synthetases. Chem Biol 18(10), 1206-1207. Details PubMed

Müller MM, Kries H, Csuhai E, Kast P, Hilvert D (2010) Design, selection, and characterization of a split chorismate mutase. Protein Sci 19(5), 1000-1010. Details PubMed

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