Biosynthetisches Design von Naturstoffen

Pourmasoumi F,^* De S,^* Peng H, Trottmann F, Hertweck C, Kries H (2022) Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase. ACS Chem Biol 17(9), 2382-2388.

Raguž L, Peng CC, Rutaganira FUN, Krüger T, Stanisic A, Jautzus T, Kries H, Kniemeyer O, Brakhage AA, King N, Beemelmanns C (2022) Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta. Angew Chem Int Ed 61(41), e202209105.

Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C (2022) Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat Chem 14(8), 884-890.

Wurlitzer JM , Stanišić A, Ziethe S, Jordan PM, Günther K, Werz O, Kries H, Gressler M (2022) Macrophage-targeting oligopeptides from Mortierella alpina. Chem Sci 13(31), 9091-9101.

Stanišić A, Hüsken A, Stephan P, Niquille DL, Reinstein J, Kries H (2021) Engineered nonribosomal peptide synthetase shows opposite amino acid loading and condensation specificity. ACS Catal 11(14), 8692-8700.

Huang HM, Stephan P, Kries H (2020) Engineering DNA-templated nonribosomal peptide synthesis. Cell Chem Biol S2451-9456(20), 30433-5.

Trottmann F, Ishida K, Franke J, Stanišić A, Ishida-Ito M, Kries H, Pohnert G, Hertweck C (2020) Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor. Angew Chem Int Ed 59(32), 13511-13515.

Wurlitzer J, Stanišić A, Wasmuth I, Jungmann S, Fischer D, Kries H, Gressler M (2020) Bacterial-like nonribosomal peptide synthetases produce cyclopeptides in the zygomycetous fungus Mortierella alpina. Appl Env Microbiol 87(3), e02051-20.

Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, García-Altares M, Willing K, Günther M, Stallforth P (2019) Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. Chem Sci 10(48), 10979-10990.