Biosynthetisches Design von Naturstoffen

Müll M, Pourmasoumi F, Wehrhan L, Nosovska O, Stephan P, Zeihe H, Vilotijevic I, Keller BG, Kries H (2023) Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S. RSC Chem Biol 4, 692-697.

Stephan P, Langley C, Winkler D, Basquin J, Caputi L, O'Connor SE, Kries H (2023) Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase. Angew Chem Int Ed Engl 62(35), e202304843.

Zhang K, Kries H (2023) Biomimetic engineering of nonribosomal peptide synthesis. Biochem Soc Trans 51(4), 1521-1532. (Review)

Pourmasoumi F,^* De S,^* Peng H, Trottmann F, Hertweck C, Kries H (2022) Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase. ACS Chem Biol 17(9), 2382-2388.

Raguž L, Peng CC, Rutaganira FUN, Krüger T, Stanišić A, Jautzus T, Kries H, Kniemeyer O, Brakhage AA, King N, Beemelmanns C (2022) Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta. Angew Chem Int Ed 61(41), e202209105.

Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C (2022) Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nat Chem 14(8), 884-890.

Wurlitzer JM, Stanišić A, Ziethe S, Jordan PM, Günther K, Werz O, Kries H, Gressler M (2022) Macrophage-targeting oligopeptides from Mortierella alpina. Chem Sci 13(31), 9091-9101.

Stanišić A, Hüsken A, Stephan P, Niquille DL, Reinstein J, Kries H (2021) Engineered nonribosomal peptide synthetase shows opposite amino acid loading and condensation specificity. ACS Catal 11(14), 8692-8700.

Huang HM, Stephan P, Kries H (2020) Engineering DNA-templated nonribosomal peptide synthesis. Cell Chem Biol S2451-9456(20), 30433-5.