Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.

Schulz JD, Patt M, Basler S, Kries H, Hilvert D, Gauthier MA, Leroux JC (2016) Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract. Adv Mater 28(7), 1455-1460. PubMed

Abstract

The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.

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Identifier

doi: 10.1002/adma.201504797 PMID: 26640034