Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
(2016) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat Chem Biol 12(1), 6-8.
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5β-reductase are highlighted.
doi: 10.1038/nchembio.1955 PMID: 26551396