Tailor-made peptide synthetases.

Kries H, Hilvert D (2011) Tailor-made peptide synthetases. Chem Biol 18(10), 1206-1207. PubMed


Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.


doi: 10.1016/j.chembiol.2011.10.006 PMID: 22035787