Tailor-made peptide synthetases.
(2011) Tailor-made peptide synthetases. Chem Biol 18(10), 1206-1207.
Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.
doi: 10.1016/j.chembiol.2011.10.006 PMID: 22035787