Biomolekulare Chemie

Liu M, Ohashi M, Hung YS, Scherlach K, Watanabe K, Hertweck C, Tang Y (2021) AoiQ catalyzes geminal dichlorination of 1,3-diketone natural products. J Am Chem Soc 143(19), 7267-7271.

Mahler L, Niehs SP, Martin K, Weber T, Scherlach K, Hertweck C, Roth M, Rosenbaum MA (2021) Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities. eLife 10, e64774.

Molloy EM, Dell M, Haensch VG, Dunbar KL, Feldmann R, Oberheide A, Seyfarth L, Kumpfmüller J, Horch T, Arndt HD, Hertweck C (2021) Enzyme-primed native chemical ligation produces autoinducing cyclopeptides in clostridia. Angew Chem Int Ed 60(19), 10670-10679.

Mullins AJ, Webster G, Kim HJ, Zhao J, Petrova YD, Ramming CE, Jenner M, Murray JAH, Connor TR, Hertweck C, Challis GL, Mahenthiralingam E (2021) Discovery of the Pseudomonas polyyne protegencin by a phylogeny-guided study of polyyne biosynthetic gene cluster diversity. mBio 12(4), e0071521.

Rose MM, Scheer D, Hou Y, Hotter VS, Komor AJ, Aiyar P, Scherlach K, Vergara F, Yan Q, Loper JE, Jakob T, van Dam NM, Hertweck C, Mittag M, Sasso S (2021) The bacterium Pseudomonas protegens antagonizes the microalga Chlamydomonas reinhardtii using a blend of toxins. Environ Microbiol 23(9), 5525-5540.

Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339.

Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nat Commun 12(1), 3864. (Review)

Scherlach K, Kuttenlochner W, Scharf DH, Brakhage AA, Hertweck C, Groll M, Huber EM (2021) Structural and mechanistic insights into C-S bond formation in gliotoxin. Angew Chem Int Ed 60(25), 14188-14194.

Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller R, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE (2021) Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrob Agents Chemother 65(1), e01373-20.

Tsunematsu Y, Maeda N, Sato M, Hara K, Hashimoto H, Watanabe K, Hertweck C (2021) Specialized flavoprotein promotes sulfur migration and spiroaminal formation in aspirochlorine biosynthesis. J Am Chem Soc 143(1), 206-213.