Divergolide congeners illuminate alternative reaction channels for ansamycin diversification.

Ding L, Franke J, Hertweck C (2015) Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Org. Biomol. Chem. 13(6), 1618-1623. PubMed

Abstract

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

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doi: 10.1039/c4ob02244k PMID: 25464499