Abstract
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.
Beteiligte Forschungseinheiten
Identifier
doi: 10.1039/c4ob02244k
PMID: 25464499