FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.

Weber M, Schaer J, Walther G, Kaerger K, Steinmann J, Rath PM, Spiess B, Buchheidt D, Hamprecht A, Kurzai O (2018) FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med Mycol 56(1), 117-120.

Abstract

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.

Leibniz-HKI-Autor*innen

Kerstin Kaerger
Oliver Kurzai
Grit Walther
Michael Weber

Identifier

doi: 10.1093/mmy/myx015

PMID: 28340175