Mahler L, Niehs SP, Martin K, Weber T, Scherlach K, Hertweck C, Roth M, Rosenbaum MA (2021) Highly parallelized droplet cultivation and prioritization on antibiotic producers from natural microbial communities. Elife 10, e64774. Details PubMed PDF

Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339. Details PubMed Open Access PDF

Edenhart S, Denneler M, Spohn M, Doskocil E, Kavscek M, Amon T, Kosec G, Smole J, Bardl B, Biermann M, Roth M, Wohlleben W, Stegmann E (2020) Metabolic engineering of Amycolatopsis japonicum for optimized production of [S,S]-EDDS, a biodegradable chelator. Metab Eng 60, 148-156. Details PubMed

Hengoju S, Wohlfeil S, Munser AS, Shvydkiv O, Boehme S, Beckert E, Tovar M, Roth M, Rosenbaum MA (2020) Optofluidic detection setup for multi-parametric analysis of microbiological samples in droplets. Biomicrofluidics 14(2), 024109. Details PubMed Open Access PDF

Tovar M, Mahler L, Buchheim S, Roth M, Rosenbaum M (2020) Monitoring and external control of pH in microfluidic droplets during microbial culturing. Microb Cell Fact 19(1), 16. Details PubMed Open Access PDF

Svensson CM*, Shydkiv O*, Dietrich S, Mahler L, Weber T, Choudhary M, Tovar M, Figge MT**, Roth M**; *authors contributed equally; *corresponding authors; **authors contributed equally (2019) Coding of experimental conditions in microfluidic droplet assays using colored beads and machine learning supported image analysis. Small 15(4), e1802384. Details PubMed

Tovar M, Hengoju S, Weber T, Mahler L, Choudhary M, Becker T, Roth M (2019) One sensor for multiple colors: Fluorescence analysis of microdroplets in microbiological screenings by frequency-division multiplexing. Anal Chem 91(4), 3055-3061. Details PubMed

Dewald C, Lüdecke C, Firkowska-Boden I, Roth M, Bossert J, Jandt KD (2018) Gold nanoparticle contact point density controls microbial adhesion on gold surfaces. Colloids Surf B Biointerfaces 163, 201-208. Details PubMed

Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M (2018) Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria. Sci Rep 8(1), 15859. Details PubMed Open Access PDF

Niehs SP, Dose B, Scherlach K, Roth M, Hertweck C (2018) Genomics-driven discovery of a symbiont-specific cyclopeptide from bacteria residing in the rice seedling blight fungus. ChemBioChem 19(20), 2167-2172. Details PubMed

Tovar M, Weber T, Hengoju S, Lovera A, Munser AS, Shvydkiv O, Roth M (2018) 3D-glass molds for facile production of complex droplet microfluidic chips. Biomicrofluidics 12(2), 024115. Details PubMed Open Access PDF

Wiegand C, Völpel A, Ewald A, Remesch M, Kuever J, Bauer J, Griesheim S, Hauser C, Thielmann J, Tonndorf-Martini S, Sigusch BW, Weisser J, Wyrwa R, Elsner P, Hipler UC, Roth M, Dewald C, Lüdecke-Beyer C, Bossert J (2018) Critical physiological factors influencing the outcome of antimicrobial testing according to ISO 22196 / JIS Z 2801. PLOS One 13(3), e0194339. Details PubMed Open Access PDF

Wink K, Mahler L, Beulig J, Piendl S, Roth M, Belder D (2018) An integrated chip-mass spectrometry and epifluorescence approach for online monitoring of bioactive metabolites from incubated Actinobacteria in picoliter droplets. Anal Bioanal Chem 410(29), 7679-7687. Details PubMed Open Access PDF

Pan X, Domin N, Schieferdecker S, Kage H, Roth M, Nett M (2017) Herpetopanone, a diterpene from Herpetosiphon aurantiacus discovered by isotope labeling. Beilstein J. Org. Chem. 13, 2458-2465. Details PDF

Lüdecke C, Roth M, Yu W, Horn U, Bossert J, Jandt KD (2016) Nanorough titanium surfaces reduce adhesion of Escherichia coli and Staphylococcus aureus via nano adhesion points Colloids Surf B Biointerfaces 145, 617-625. Details PubMed

Walther E, Boldt S, Kage H, Lauterbach T, Martin K, Roth M, Hertweck C, Sauerbrei A, Schmidtke M, Nett M (2016) Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties GMS Infect Dis 4, Doc08. Details Open Access

Elschner T, Lüdecke C, Kalden D, Roth M, Löffler B, Jandt KD, Heinze T (2015) Zwitterionic cellulose carbamate with regioselective substitution pattern: a coating material possessing antimicrobial activity Macromol Biosci 16(4), 522-534. Details PubMed

Mahler L, Tovar M, Weber T, Brandes S, Rudolph MM, Ehgartner J, Mayr T, Figge MT, Roth M, Zang E (2015) Enhanced and homogeneous oxygen availability during incubation of microfluidic droplets. RSC Advances 5, 101871-101878. Details Open Access PDF Supplement

Phieler R, Merten D, Roth M, Büchel G, Kothe E (2015) Phytoremediation using microbially mediated metal accumulation in Sorghum bicolor Environ Sci Pollut Res 22(24), 19408-19416. Details PubMed

Schäberle TF, Schmitz A, Zocher G, Schiefer A, Kehraus S, Neu E, Roth M, Vassylyev DG, Stehle T, Bierbaum G, Hoerauf A, Pfarr K, König GM (2015) Insights into Structure–Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives J Nat Prod 78(10), 2505-2509. Details PubMed Supplement

Schieferdecker S, Domin N, Hoffmeier C, Bryant DA, Roth M, Nett M (2015) Structure and absolute configuration of auriculamide, a natural product from the predatory bacterium Herpetosiphon aurantiacus. Eur J Org Chem 14, 3057-3062. Details

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674. Details PubMed

van Dissel D, Claessen D, Roth M, van Wezel GP (2015) A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories Microbial Cell Factories 14:44, Details Open Access PDF

Kroll K, Pähtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O (2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as important contributor to hypoxic survival. Eukaryot Cell 13(9), 1241-1253. Details PubMed

Lüdecke C, Jandt KD, Siegismund D, Kujau MJ, Zang E, Rettenmayr M, Bossert J, Roth M (2014) Reproducible biofilm cultivation of chemostat-grown Escherichia coli and investigation of bacterial adhesion on biomaterials using a non-constant-depth film fermenter. PLOS One 9(1), e84837. Details PubMed Open Access PDF

Schieferdecker S, Exner TE, Gross H, Roth M, Nett M (2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J Antibiot 67(7), 519-525. Details PubMed

Schmitz A, Kehraus S, Schäberle TF, Neu E, Almeida C, Roth M, König GM (2014) Corallorazines from the myxobacterium Corallococcus coralloides. J Nat Prod 77(1), 159-163. Details PubMed Open Access PDF

Schütze E, Ahmed E, Voit A, Klose M, Greyer M, Svatoš A, Merten D, Roth M, Holmström SJ, Kothe E (2014) Siderophore production by streptomycetes-stability and alteration of ferrihydroxamates in heavy metal-contaminated soil. Environ Sci Pollut Res Int 22(24), 19376-19383. Details PubMed

Schütze E, Klose M, Merten D, Nietzsche S, Senftleben D, Roth M, Kothe E (2014) Growth of streptomycetes in soil and their impact on bioremediation. J Hazard Mater 267, 128-135. Details PubMed

Cao J, Kürsten D, Krause K, Kothe E, Martin K, Roth M, Köhler JM (2013) Application of micro-segmented flow for two-dimensional characterization of the combinatorial effect of zinc and copper ions on metal-tolerant Streptomyces strains. Appl Microbiol Biotechnol 97(20), 8923-8930. Details PubMed

Lüdecke C, Bossert J, Roth M, Jandt KD (2013) Physical vapor deposited titanium thin films for biomedical applications: Reproducibility of nanoscale surface roughness and microbial adhesion properties. Applied Surface Science 280, 578-589. Details

Schütze E, Miltner A, Nietzsche S, Achtenhagen J, Klose M, Merten D, Greyer M, Roth M, Kästner M, Kothe E (2013) Live and death of streptomycetes in soil - what happens to the biomass? Journal of Plant Nutrition and Soil Science 176, 665-673. Details

Zang E*, Brandes S*, Tovar M, Martin K, Mech F, Horbert P, Henkel T, Figge MT, Roth M (2013) Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets. Lab Chip 13(18), 3707-3713, *authors contributed equally. Details PubMed Open Access

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C (2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177. Details PubMed

Moebius N, Ross C, Scherlach K, Rohm B, Roth M, Hertweck C (2012) Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli. Chem Biol 19(9), 1164-1174. Details PubMed Open Access PDF

Roth M, Martin K, Zang E, Nett M, Henkel T (2012) A microfluidics-based approach to drug discovery. Biomed Tech (Berl) 57(SI-1 Track-B), 270. Details

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068. Details PubMed

Scherlach K, Sarkar A, Schroeckh V, Dahse HM, Roth M, Brakhage AA, Horn U, Hertweck C (2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839. Details PubMed

Vödisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O (2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5), 2508-2524. Details PubMed

Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C (2010) Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line. Angew Chem Int Ed Engl 49(8), 1460-1464. Details PubMed

Lincke T, Behnken S, Ishida K, Roth M, Hertweck C (2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013. Details PubMed

Schachtschabel D, Menzel KD, Krauter G, David A, Roth M, Horn U, Boland W, Wöstemeyer J, Schimek C (2010) Production and derivate composition of trisporoids in extended fermentation of Blakeslea trispora. Appl Microbiol Biotechnol 88(1), 241-249. Details PubMed

Werneburg M, Busch B, He J, Richter ME, Xiang L, Moore BS, Roth M, Dahse HM, Hertweck C (2010) Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc 132(30), 10407-10413. Details PubMed Open Access

Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C (2009) Polyketide-chain branching by an enzymatic Michael addition. Angew Chem Int Ed Engl 48(27), 5001-5004. Details PubMed

Peschel G, Dahse HM, Konrad A, Wieland GD, Mueller PJ, Martin DP, Roth M (2008) Growth of keratinocytes on porous films of poly(3-hydroxybutyrate) and poly(4-hydroxybutyrate) blended with hyaluronic acid and chitosan. J Biomed Mater Res A 85(4), 1072-1081. Details PubMed

Partida-Martinez LP, de Looss CF, Ishida K, Ishida M, Roth M, Buder K, Hertweck C (2007) Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Appl Environ Microbiol 73(3), 793-797. Details PubMed Open Access PDF

Partida-Martinez LP, Groth I, Schmitt I, Richter W, Roth M, Hertweck C (2007) Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus. Int J Syst Evol Microbiol 57(Pt 11), 2583-2590. Details PubMed Open Access PDF Supplement

Herold K, Gollmick FA, Groth I, Roth M, Menzel KD, Möllmann U, Gräfe U, Hertweck C (2005) Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Chemistry 11(19), 5523-5530. Details PubMed

Köhler JM, Henkel T, Grodrian A, Kirner T, Roth M, Martin K, Metze J (2004) Digital reaction technology by micro segmented flow—components, concepts and applications Chemical Engineering Journal 101, 201-216. Details

Martin K, Henkel T, Baier V, Grodrian A, Schön T, Roth M, Michael Köhler J, Metze J (2003) Generation of larger numbers of separated microbial populations by cultivation in segmented-flow microdevices. Lab Chip 3(3), 202-207. Details PubMed