Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum.

Ding L, Dahse HM, Hertweck C (2012) Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum. J Nat Prod 75(4), 617-621.

Abstract

Several unusual alkaloids, N-2-methylpropyl-2-methylbutenamide (1), 2-acetyl-1,2,3,4-tetrahydro-β-carboline (2), fusarine (3), fusamine (4), and 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (5), were isolated from the culture broth of Fusarium incarnatum (HKI0504), an endophytic fungus of the mangrove plant Aegiceras corniculatum. Compounds 2, 4, and 5 exhibit weak antiproliferative and cytotoxic activities against HUVEC, K-562, and HeLa human cell lines, respectively.

Leibniz-HKI-Autor*innen

Hans-Martin Dahse
Christian Hertweck

Identifier

doi: 10.1021/np2008544

PMID: 22439674