Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system.

Huang X, He J, Niu X, Menzel KD, Dahse HM, Grabley S, Fiedler HP, Sattler I, Hertweck C (2008) Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system. Angew Chem Int Ed Engl 47(21), 3995-3998.

Abstract

A natural benzopyren: The title compound 1 was discovered by chemical metabolite profiling of a large-scale fermentation of Streptomyces lavendulae. Biological evaluation of the peri-fused pentacyclic compound revealed antitumor activity against several cell lines. The co-occurrence of an angucyclic polyketide with an identical ring-substitution pattern suggests that 1 is biosynthesized from an angular decaketide and a C3 building block.

Leibniz-HKI-Autor*innen

Klaus-Dieter Menzel

Identifier

doi: 10.1002/anie.200800083

PMID: 18412200