Huijuan Guo
Forschungsschwerpunkte
  • discovery of new bioactive secondary metabolites
  • structure elucidation of natural products
  • protein identification and analysis
Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

2009-2014 Doctoral thesis in chemistry at the Max-Planck-Institute for Chemical Ecology, Jena
2007–2009 Research assistant at the Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2005-2007 Master thesis in natural product chemistry, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China
2004-2005 Master study in biochemistry and molecular biology, Graduate University of Chinese Academy of Science, Beijing, P. R. China
2000-2004 Bachelor study, Shenyang Agriculture University, Shenyang, P. R. China

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

2009-2014 International Leibniz Research School for Microbial and Biomolecular Interactions,
ILRS Jena, Germany
2009 - Gesellschaft Chinesischer Chemiker und Chemieingenieuer in der Bundesrepublik
Deutschland
Publikationen

Guo H, Schwitalla JW, Benndorf R, Baunach M, Steinbeck C, Görls H, de Beer ZW, Regestein L, Beemelmanns C (2020) Gene Cluster Activation in a Bacterial Symbiont Leads to Halogenated Angucyclic Maduralactomycins and Spirocyclic Actinospirols. Org Lett [Epub ahead of print] Details PubMed

Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G (2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem Biol 14(9), 2088-2094. Details PubMed

Guo H, Roman D, Beemelmanns C (2019) Tropolone natural products. Nat Prod Rep 36(8), 1137-1155. Details PubMed Open Access

Peña-Ortiz L, Graça A P, Guo H, Braga D, Köllner T G, Regestein L, Beemelmanns C, Lackner G (2019) Biosynthesis of the redox cofactor mycofactocin comprises oligoglycosylation by MftF in Mycolicibacterium smegmatis Details Open Access

Benndorf R, Guo H, Sommerwerk E, Weigel C, Garcia-Altares M, Martin K, Hu H, Kuefner M, de Beer ZW, Poulsen M, Beemelmanns C (2018) Natural products from Actinobacteria associated with fungus-growing termites. Antibiotics 7(3), pii: E83. Details PubMed Open Access

Guo H, Benndorf R, König S, Leichnitz D, Weigel C, Peschel G, Berthel P, Kaiser M, Steinbeck C, Werz O, Poulsen M, Beemelmanns C (2018) Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS‐derived Pyrans. Chem Eur J 24(44), 11319-11324. Details PubMed

Guo H, Schmidt A, Stephan P, Raguž L, Braga D; Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins. ChemBioChem 19(21), 2307-2311. Details PubMed

Rischer M, Raguz L, Guo H, Keiff F, Diekert G, Goris T, Beemelmanns C (2018) Biosynthesis, Synthesis and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995. Details PubMed

Guo H, Benndorf R, Leichnitz D, Klassen JL, Vollmers J, Görls H, Steinacker M, Weigel C, Dahse HM, Kaster AK, de Beer ZW, Poulsen M, Beemelmanns C (2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2. Chem Eur J 23(39), 9338-9345. Details PubMed

Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C (2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed

Beemelmanns C, Guo H, Rischer M, Poulsen M (2016) Natural products from microbes associated with insects. Beilstein J Org Chem 12, 314-327. Details PubMed Open Access

Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C (2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed

Rischer M, Klassen J, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. Details PubMed

Klassen JL, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed

Klassen JL, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed

Shao Y, Arias-Cordero E, Guo H, Bartram S, Boland W (2014) In vivo Pyro-SIP assessing active gut microbiota of the cotton leafworm, Spodoptera littoralis. PLOS One 9(1), e85948. Details PubMed

Guo H, Wielsch N, Hafke JB, Svatoš A, Mithöfer A, Boland W (2013) A porin-like protein from oral secretions of Spodoptera littoralis larvae induces defense-related early events in plant leaves. Insect Biochem Mol Biol 43(9), 849-858. Details PubMed

Chen Y, Guo H, Du Z, Liu XZ, Che Y, Ye X (2009) Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif 42(6), 838-847. Details PubMed

Guo H, Sun B, Gao H, Chen X, Liu S, Yao X, Liu X, Che Y (2009) Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum. J Nat Prod 72(12), 2115-2119. Details PubMed

Guo H, Sun B, Gao H, Niu S, Liu X, Yao X, Che Y (2009) Trichocladinols A–C, Cytotoxic Metabolites from a Cordyceps-Colonizing Ascomycete Trichocladium opacum Eur J Org Chem 32, 5525-5530. Details

Guo H, Hu H, Liu S, Liu X, Zhou Y, Che Y (2007) Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp. J Nat Prod 70(9), 1519-1521. Details PubMed

Hu H, Guo H, Li E, Liu X, Zhou Y, Che Y (2006) Decaspirones F-I, bioactive secondary metabolites from the saprophytic fungus Helicoma viridis. J Nat Prod 69(12), 1672-1675. Details PubMed