Florian Kloß

Dr. Florian Kloß

Transfergruppe Antiinfektiva · Leitung

Telefon: +49 3641 532-1356 Telefax: +49 3641 532-2356 E-Mail: florian.kloss@leibniz-hki.de

Publikationen

Roman D, Raguž L, Keiff F, Meyer F, Barthels F, Schirmeister T, Kloss F, Beemelmanns C (2020) Modular solid-phase synthesis of antiprotozoal barnesin derivatives. Org Lett 22(10), 3744-3748. Details PubMed

Dunbar KL, Dell M, Molloy EM, Kloss F, Hertweck C (2019) Reconstitution of iterative thioamidation in closthioamide biosynthesis reveals a novel nonribosomal peptide backbone-tailoring strategy. Angew Chem Int Ed 58(37), 13014-13018. Details PubMed Open Access PDF

Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S (2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19. Details PubMed Open Access PDF

Haensch VG, Neuwirth T, Steinmetzer J, Kloss F, Beckert R, Gräfe S, Kupfer S, Hertweck C (2019) Metal-free aryl cross-coupling directed by traceless linkers. Chem Eur J 25(70), 16068-16073. Details PubMed Open Access PDF

Kloss F, Gerbach S (2018) Hürden und Aussichten neuer antimikrobieller Konzepte in Forschung und Entwicklung. [Obstacles and perspectives of new antimicrobial concepts within research and development]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 61(5), 595-605. Details PubMed PDF

Kloss F, Neuwirth T, Haensch VG, Hertweck C (2018) Metal-free synthesis of pharmaceutically important biaryls by photosplicing. Angew Chem Int Ed 57(44), 14476-14481. Details PubMed

Kloss F, Krchnak V, Krchnakova A, Schieferdecker S, Dreisbach J, Krone V, Möllmann U, Hoelscher M, Miller MJ (2017) In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation. Angew Chem Int Ed 56(8), 2187-2191. Details PubMed

Chiriac AI, Kloss F, Krämer J, Vuong C, Hertweck C, Sahl HG (2015) Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. J Antimicrob Chemother 70(9), 2576-2588. Details PubMed

Kloss F, Chiriac AI, Hertweck C (2014) Mapping of the modular closthioamide architecture reveals crucial motifs of polythioamide antibiotics. Chemistry 20(47), 15451-15458. Details PubMed

Pidot SJ, Coyne S, Kloß F, Hertweck C (2014) Antibiotics from neglected bacterial sources. Int J Med Microbiol 304(1), 14-22. Details PubMed

Ross C, Scherlach K, Kloss F, Hertweck C (2014) The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria. Angew Chem Int Ed Engl 53(30), 7794-7798. Details PubMed

Behnken S, Lincke T, Kloss F, Ishida K, Hertweck C (2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51(10), 2425-2428. Details PubMed