Christine Beemelmanns

Dr. Christine Beemelmanns

Chemische Biologie der Mikroben-Wirt Interaktionen · Abteilungsleiterin

Telefon: +49 3641 532-1525 Telefax: +49 3641 532-2525 E-Mail: christine.beemelmanns@leibniz-hki.de

Forschungsschwerpunkte
  • Isolierung und Strukturaufklärung von Signalmolekülen und antimikrobiellen Naturstoffen
  • Charakterisierung von Interkationen zwischen Mikroben und Eukaryoten
  • Totalsynthese von Naturstoffen und chemische Derivatisierung
Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

Seit 12/2013 Nachwuchsgruppenleiterin am Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, HKI, Chemische Biologie der Mikroben-Wirt-Interaktionen
2011-2013 Postdoc an der Harvard Medical School, Harvard University, unter der Anleitung von Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology
2010-2011 Postdoc am Tokyo Institute of Technology, Chemische Fakultät, (Tokyo, Japan) unter der Anleitung von Prof. K. Suzuki
2010 Dr. rer. nat. in Chemie, summa cum laude, Freie Universität Berlin
2007-2010 Doktorarbeit, Organische Chemie unter der Anleitung von Prof. H.-U. Reißig an der Freien Universität Berlin (Deutschland)
2006-2007 Forschungsaufenthalt am RIKEN, Chemie, in der Arbeitsgruppe von Prof. M. Sodeoka (Japan)
2001-2006 Studium Chemie, Diplom an der RWTH Aachen (Deutschland)

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

2014-2015 Postdoktoranden-Stipendium der Daimler und Benz Stiftung und Reinhard Frank Stiftung
Seit 2014 Mitglied VAAM, FEMS und IUMS
Seit 2014 Mitglied Dechema
Seit 2014 Mitglied National Research Foundation of Korea
2011-2013 Postdoktoranden-Stipendium der Leopoldina Nationale Akademie der Wissenschaften; Postdoktoranden-Stipendium der DFG abgelehnt
2011 Ernst-Reuter-Preis der Freien Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Deutschland)
2010-2011 Postdoktoranden-Stipendium des DAAD
Seit 2010 Kommissionsmitglied, Studienstiftung des deutschen Volkes
2007-2010 ideelles Doktorandenstipendium der Studienstiftung des deutschen Volkes
2007-2009 Doktorandenstipendium des Fond der Chemischen Industrie (VCI)
2006 Springorum-Gedenkmünze der RWTH Aachen (Aachen, Germany)
2006 Procter and Gamble Award, Fachgruppe Chemie der RWTH Aachen
2006-2007 RIKEN Stipendium der Studienstiftung des deutschen Volkes
2004-2006 Chemie-Studium: Stipendium der Studienstiftung des deutschen Volkes
Seit 2003 Mitglied der GDCH
2003 Chemie-Preis der Fakultät für Mathematik, Informatik, Naturwissenschaften RWTH Aachen
2003 Schöneborn Preis der Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Deutschland)
Publikationen

Beemelmanns C, Nitsch D, Bentz C, Reissig HU (2019) Stereoselective Cascade Cyclizations with Samarium Diiodide to Tetracyclic Indolines - Precursors of Fluorostrychnines and Brucine. Chemistry 25(37), 8780-8789. Details PubMed

Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G (2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem Biol 14(9), 2088-2094. Details PubMed

Burkhardt I, Kreuzenbeck N, Beemelmanns C, Dickschat J (2019) Mechanistic Characterization of Three Sesquiterpene Synthases from the Termite-Associated Fungus Termitomyces. Org Biol Chem 17(13), 3348-3355. Details PubMed

Conlon BH, Aanen DK, Beemelmanns C, de Beer ZW, De Fine Lichte HH, Gunde-Cimerman N, Schiøtt M, Poulsen M (2019) Reviewing the taxonomy of Podaxis: opportunities for understanding extreme fungal lifestyles. Fungal Biol 123(3), 183-187. (Review) Details PubMed Open Access

Guo H, Roman D, Beemelmanns C (2019) Tropolone natural products. Nat Prod Rep 36(8), 1137-1155. Details PubMed Open Access

Klassen JL, Lee SR, Poulsen M, Beemelmanns C*, Kim KH* (2019) Efomycins K and L from a Termite-associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin Front Microbiol 10, 1739. Details PubMed Open Access

Lee SR, Küfner M, Park M, Jung WH, Choi SU, Beemelmanns C, Kim KH (2019) Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana Org Chem Front 6, 162-166. Details Open Access

Lee SR, Lee D, Eom HJ, Rischer M, Ko YJ, Kang KS, Kim CS, Beemelmanns C,* Kim KH* (2019) Hybrid Polyketides from a Hydractinia-Associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin Mar Drugs 17(11), 606. Details Open Access

Leichnitz D, Pflanze S, Beemelmanns C (2019) Stereoselective Synthesis of Unnatural (2S,3S)-6-Hydroxy-4-Sphingenine-Containing Sphingolipids. Org Biomol Chem 17(29), 6964-6969. Details PubMed Open Access

Otani S, Challinor V, Kreuzenbeck N, Kildgaard S, Christensen S, Larsen L, Aanen D, Rasmussen SA, Beemelmanns C, Poulsen M (2019) Disease-free monoculture farming by fungus-growing termites. Sci Rep 9(1), 8819. Details PubMed Open Access

Peña-Ortiz L, Graça A P, Guo H, Braga D, Köllner T G, Regestein L, Beemelmanns C, Lackner G (2019) Biosynthesis of the redox cofactor mycofactocin comprises oligoglycosylation by MftF in Mycolicibacterium smegmatis Details Open Access

Raguz L, Beemelmanns C (2019) Ursprung und Funktionen der Sphingolipide. Nachrichten aus der Chemie 67(2), 66-70. (Review) Details PDF

Rischer M, Lee SR, Eom HJ, Park HB, Vollmers J, Kaster AK, Shin JH, Oh DC, Kim KH, Beemelmanns C* (2019) Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67 Org Chem Front 6, 1084-1093. Details Open Access

Yoon SY, Lee SR, Hwang JY, Benndorf R, Beemelmanns C, Chung SJ, Kim KH (2019) Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis. Nutrients 11(4), pii: E765. Details PubMed Open Access

Benndorf R, Guo H, Sommerwerk E, Weigel C, Garcia-Altares M, Martin K, Hu H, Kuefner M, de Beer ZW, Poulsen M, Beemelmanns C (2018) Natural products from Actinobacteria associated with fungus-growing termites. Antibiotics 7(3), pii: E83. Details PubMed Open Access

Guo H, Benndorf R, König S, Leichnitz D, Weigel C, Peschel G, Berthel P, Kaiser M, Steinbeck C, Werz O, Poulsen M, Beemelmanns C (2018) Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS‐derived Pyrans. Chem Eur J 24(44), 11319-11324. Details PubMed

Guo H, Schmidt A, Stephan P, Raguž L, Braga D; Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins. ChemBioChem 19(21), 2307-2311. Details PubMed

Lee RS, Lee D, Yu JS, Benndorf R, Lee S, Lee DS, Huh J, de Beer ZW, Kim YH, Beemelmanns C, Kang KS, Kim KH (2018) Natalenamides A-C, Cyclic Tripeptides from the Termite-associated Actinomadura sp. RB99. Molecules 23(11), pii: E3003. Details PubMed Open Access

Lee SR, Song JH, Song JH, Ko HJ, Baek JY, Trinh TA, Beemelmanns C, Yamabe N, Kim KH (2018) Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line. Int J Mol Sci 19(9), E2640. Details PubMed Open Access

Park YJ, Lee SR, Kim DM, Yu JS, Beemelmanns C, Chung KH, Kim KH (2018) The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells. Molecules 23(10), pii: E2568. Details PubMed Open Access

Rischer M, Raguz L, Guo H, Keiff F, Diekert G, Goris T, Beemelmanns C (2018) Biosynthesis, Synthesis and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995. Details PubMed

Wichard T, Beemelmanns C (2018) Role of chemical mediators in aquatic interactionas across the prokaryote eukaryote boundary. J Chem Ecol 44(11), 1008-1021. (Review) Details PubMed

Beemelmanns C, Ramadhar TR, Kim KH, Klassen JL, Cao S, Wyche TP, Hou Y, Poulsen M, Bugni TS, Currie CR, Clardy J (2017) Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett 19(5), 1000-1003. Details PubMed

Benndorf R, Leichnitz D, Rischer M, Beemelmanns C (2017) Wie sich Bakterien schützen. Nachrichten aus der Chemie 65(1), 21-25. (Review) Details Open Access

Guo H, Benndorf R, Leichnitz D, Klassen JL, Vollmers J, Görls H, Steinacker M, Weigel C, Dahse HM, Kaster AK, de Beer ZW, Poulsen M, Beemelmanns C (2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2. Chem Eur J 23(39), 9338-9345. Details PubMed

Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C (2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed

Leichnitz D, Raguž L, Beemelmanns C (2017) Total synthesis and functional analysis of microbial signalling molecules. Chem Soc Rev 46(20), 6330-6344. (Review) Details PubMed

Rischer M, Leichnitz D, Beemelmanns C (2017) Bakterien-induzierte Morphogenese mariner Eukaryoten Wissenschaft. BIOSpektrum 2017(6), 634-637. (Review) Details Open Access

Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J (2017) Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org Lett 19(7), 1772-1775. Details PubMed

Beemelmanns C, Guo H, Rischer M, Poulsen M. (2016) Natural products from microbes associated with insects. Beilstein J Org Chem 12, 314-327. Details PubMed Open Access

Cantley AM, Woznica A, Beemelmanns C, King N, Clardy J (2016) Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J Am Chem Soc 138(13), 4326-4329. Details PubMed

Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C (2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed

Kang HR, Lee D, Benndorf R, Jung WH, Beemelmanns C, Kang KS, Kim KH (2016) Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1. J Nat Prod 79(12), 3072-3078. Details PubMed

Lee SR, Beemelmanns C, Tsumac LMM, Clardy J, Cao S, Kim KH (2016) A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT Nat Prod Commun 4(11), 461-463. Details

Rischer M, Klassen J, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. Details PubMed

Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N (2016) Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A 113(28), 7894-7899. Details PubMed

Beemelmanns C, Reissig H.-U. (2015) Evolution of a Short Route to Strychnine by Using the Samarium Diiodide-Induced Cascade Cyclization as a Key Step Chemistry - A European Journal 21(23), 8416-8425. Details PubMed

Beemelmanns C, Reissig H.-U. (2015) Strychnine as Target - Samarium Diiodide as Tool - A Personal Story The Chemical Record 15(5), 872-885. Details PubMed

Kim KH, Beemelmanns C, Clardy J, Cao S (2015) A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth Bioorg. Med. Chem. Lett. 14(25), 2834-2836. Details PubMed

Klassen JL, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed

Klassen JL, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed

Beemelmanns C, Woznica A, Alegado RA, Cantley AM, King N, Clardy J (2014) Synthesis of the rosette-inducing factor RIF-1 and analogs. J. Am. Chem. Soc. 136(29), 10210-10213. Details PubMed

Kim KH, Beemelmanns C, Murillo C, Guillén A, Umaña L, Tamayo-Castillo G., Kim SN, Clardy J, Cao, S (2014) Naphthalenones and isocoumarins from a Costa Rican fungus Xylariaceae sp. CR1546C Journal of Chemical Research 38(12), 722-725. Details

Kim KH, Ramadhar TR, Beemelmanns C, Cao S, Poulsen M, Currie CR, Clardy J (2014) Natalamycin A, an ansamycin from a termite-associated Streptomyces sp Chem. Sci. 5(11), 4333-4338. Details PubMed

Ramadhar TR, Beemelmanns C, Currie CR, Clardy J (2014) Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 67(1), 53-58. Details PubMed

Beemelmanns C, Gross S, Reissig HU (2013) Towards the core structure of Strychnos alkaloids using samarium diiodide-induced reactions of indole derivatives. Chemistry 19(52), 17801-17808. Details PubMed

Beemelmanns C, Husmann R, Whelligan DK, Özcubukçu S, Bolm C (2012) Planar Chiral Disilanols and Diols as H-Bonding Asymmetric Organocatalysts Eur. J. Org. Chem. , 3373-3376. Details

Beemelmanns C, Lentz D, Reissig HU (2011) Samarium diiodide induced cyclizations of γ-, δ- and ε-indolyl ketones: reductive coupling, intermolecular trapping, and subsequent transformations of indolines. Chemistry 17(35), 9720-9730. Details PubMed

Beemelmanns C, Reissig HU (2011) Samarium diiodide induced ketyl-(het)arene cyclisations towards novel N-heterocycles. Chem Soc Rev 40(5), 2199-2210. Details PubMed

Beemelmanns C, Reissig HU (2011) New Samarium Diiodide Induced Cyclizations Pure Appl. Chem. 83, 507-518. Details

Beemelmanns C, Blot V, Gross S, Lentz D, Reissig HU (2010) Highly Diastereoselective Samarium Diiodide Induced Ketyl Cyclizations of Indole and Pyrrole Derivatives – Scope and Limitations. Eur J Org Chem 2010(14), 2716-2732. Details

Beemelmanns C, Reissig HU (2010) A short formal total synthesis of strychnine with a samarium diiodide induced cascade reaction as the key step. Angew Chem Int Ed Engl 49(43), 8021-8025. Details PubMed

Beemelmanns C, Reissig HU (2009) Highly diastereoselective samarium diiodide induced cyclizations of new 3-substituted indole derivatives. Org Biomol Chem 7(21), 4475-4480. Details PubMed

Beyler M, Beemelmanns C, Heitz V, Sauvage JP (2009) Various Synthetic Routes to a Gable-Like Bis(porphyrin) Constructed on a 1,10-Phenanthroline Chelate Eur. J. Org. Chem. , 2801-2805. Details

Monguchi D, Beemelmanns C, Hashizume D, Hamashima Y, Sodeoka M (2008) Catalytic asymmetric conjugate reduction with ethanol: A more reactive system Pd(II)–iPr-DUPHOS complex with molecular sieves 4A Journal of Organometallic Chemistry 693(5), 867-873. Details

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