Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum.

Guo H, Sun B, Gao H, Chen X, Liu S, Yao X, Liu X, Che Y (2009) Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum. J Nat Prod 72(12), 2115-2119. PubMed

Abstract

New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.

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doi: 10.1021/np900654a PMID: 19919067