
Prof. Dr. med. Marie von Lilienfeld-Toal
Nationales Referenzzentrum für Invasive Pilzinfektionen Infektionen in der Hämatologie/Onkologie · Leiterin
Telefon: +49 3641 532-1720 Telefax: +49 3641 532-2720 E-Mail: marie.lilienfeld-toal@leibniz-hki.de
- Tumor- und Infektionsimmunologie
- Epidemiologie von Infektionen immunsupprimierter Patienten
- Klinische Diagnostik- und Therapiestudien
Wissenschaftlicher Werdegang
2014 | stellvertretende Leitung Nationales Referenzzentrum für invasive Pilzinfektionen |
2013 | W2-Professur für Infektionsforschung in der Hämatologie und Onkologie, Med. Fakultät, Friedrich-Schiller Universität Jena |
2010 | Habilitation im Fachgebiet Innere Medizin, Rheinische Friedrich-Wilhelms Universität Bonn |
2008 – 2013 | Oberärztin in der Hämatologie/Onkologie (Med. Klinik III), Universitätsklinikum Bonn |
2007 – 2008 | EBMT Fellowship Bone Marrow Transplantation Program, Leeds, UK |
2007 | Anerkennung des Schwerpunktes Hämatologie/Onkologie |
2006 | Facharzt Innere Medizin |
2003 – 2004 | Gerok Stipendium im Rahmen des BonFor Förderungsprogrammes Med. Fakultät Bonn |
1999 – 2007 | AiP/Assistenzärztin Allgemeine Innere Medizin, Universitätsklinikum Bonn |
1999 | Promotion in der Klinischen Pharmakologie, „magna cum laude“ Med. Fakultät Rheinische Friedrich-Wilhelms Universität Bonn |
1998 | Staatsexamen Humanmedizin |
Auszeichnungen · Ämter · wissenschaftliche Aktivitäten
seit 2013 | Mitglied der Ethikkommission, Med. Fakultät der FSU Jena |
seit 2013 | Vorstandsmitglied der Arbeitsgemeinschaft für Infektionen in der Hämatolgie und Onkologie (AGIHO) der Deutschen Gesellschaft für Hämatologie und internistische Onkologie (DGHO) |
seit 2008 | Mitglied der AGIHO |
2008 – 2010 | Lehrbeauftragte der Med. Klinik III der Universitätsklinik Bonn |
2002 – 2006 | Mitglied der Satzungskommission der Med. Fakultät der Rheinischen Friedrich-Wilhelms Universität Bonn |
2009 | Best Abstract DGHO |
2008 | Posterpreis |
seit 2004 | Gutachterin verschiedener Zeitschriften |
(2020) Human mucosal-associated invariant T cells respond to Mucorales species in a MR1-dependent manner. Med Mycol , myaa103. Details PubMed
(2020) Frailty impairs the feasibility of induction therapy but not of maintenance therapy in elderly myeloma patients: final results of the German Maintenance Study (GERMAIN). J Cancer Res Clin Oncol 146(3), 749-759. Details PubMed PDF
(2020) Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study. Leukemia 34(7), 1949-1953. Details PubMed Open Access PDF
(2020) Evidence-based management of COVID-19 in cancer patients: Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). Eur J Cancer 140, 86-104. Details PubMed Open Access PDF
(2020) Long-term follow-up of Cladribine, high-dose Cytarabine, and Idarubicin as salvage treatment for relapsed acute myeloid leukemia and literature review. Eur J Haematol 104(6), 538-545. Details PubMed
(2020) Caring for older adults with multiple myeloma during the COVID-19 Pandemic: Perspective from the international forum for optimizing care of older adults with myeloma. J Geriatr Oncol 11(5), 764-768. Details PubMed Open Access PDF
(2020) Detection of community-acquired respiratory viruses in allogeneic stem-cell transplant recipients and controls-A prospective cohort study. Transpl Infect Dis 22(6), e13415. Details PubMed Open Access PDF
(2020) Treatment of invasive fungal diseases in cancer patients-Revised 2019 recommendations of the infectious diseases working party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Mycoses 63(7), 653-682. Details PubMed
(2020) COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry. Ann Hematol 100(2), 383-393. Details PubMed Open Access PDF
(2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20. Details PubMed Open Access PDF Supplement
(2020) Community-acquired respiratory viruses in oncology: Lessons to be learnt from the SARS-CoV-2 pandemic. Oncol Res Treat 43(6), 262-263. Details PubMed Open Access PDF
(2020) Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases. Leukemia 34(6), 1487-1494. (Review) Details PubMed Open Access PDF
(2019) The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey. Ann Hematol 98(3), 713-722. Details PubMed
(2019) Controlling intestinal colonization of high-risk haematology patients with ESBL-producing Enterobacteriaceae: a randomized, placebo-controlled, multicentre, Phase II trial (CLEAR). J Antimicrob Chemother 74(7), 2065-2074. Details PubMed
(2019) Measuring phagocytosis of Aspergillus fumigatus conidia by human leukocytes using flow cytometry. J Vis Exp (154), Details PubMed
(2019) Fast and quantitative evaluation of human leukocyte interaction with Aspergillus fumigatus conidia by flow cytometry. Cytometry A 95(3), 332-338. Details PubMed Open Access PDF
(2019) Continuous high dosing of lenalidomide in relapsed, refractory or older newly diagnosed acute myeloid leukemia patients not suitable for other treatment options - results from a phase I study. Haematologica 104(2), e63-e64. Details PubMed
(2019) MAIT cell activation by fungal pathogens. Methods Mol Biol 2098, 167-177. Details PubMed
(2019) Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 98(5), 1051-1069. Details PubMed
(2019) Das Deutsche Pilz-Keratitis-Register: Erste Ergebnisse einer multizentrischen Erhebung [The german keratomycosis registry: Initial results of a multicenter survey]. Ophthalmologe 116(10), 957-966. Details PubMed Open Access PDF
(2019) Invasive fungal infection. Dtsch Arztebl Int 116(16), 271-278. Details PubMed Open Access PDF
(2019) Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation. Haematologica [Epub ahead of print] Details PubMed
(2018) Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner. Eur J Immunol 48(10), 1698-1706. Details PubMed Open Access
(2018) Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors-Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). Ann Oncol 29(6), 1354-1365. Details PubMed
(2018) Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO). Mycoses 61(11), 796-813. Details PubMed Open Access PDF
(2018) Challenges in infectious diseases for haematologists. Oncol Res Treat 41(6), 406-410. Details PubMed
(2017) Screening and contact precautions - A survey on infection control measures for multidrug-resistant bacteria in German university hospitals. Antimicrob Resist Infect Control 6, 37. Details PubMed
(2017) Safety issues and management of toxicities associated with new treatments for multiple myeloma. Expert Rev Hematol 10(3), 193-205. (Review) Details PubMed
(2017) Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 96(11), 1775-1792. Details PubMed
(2017) Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO). Eur J Clin Microbiol Infect Dis 36(3), 565-573. Details PubMed
(2017) Primary propPrimary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology. Ann Hematol [Epub ahead of print] Details PubMed
(2017) Measurement of piperacillin plasma concentrations in cancer patients with suspected infection. Infection 45(5), 629-636. Details PubMed
(2017) Fusarium Keratitis in Germany. J Clin Microbiol 55(10), 2983-2995. Details PubMed
(2016) Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia. Ann Hematol 95(6), 1001-1009. Details PubMed
(2016) Case report: false positive elevated serum-galactomannan levels after autologous hematopoietic stem cell transplantation caused by oral nutritional supplements. Clin Case Rep. 4(5), 505-508. Details PubMed
(2016) Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur J Cancer 67, 200-212. Details PubMed
(2015) Comparison of antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin (CIP) in patients with acute myeloid leukemia. Support Care Cancer 23(5), 1321-1329. Details PubMed
(2015) Antiviral prophylaxis in patients with solid tumours and haematological malignancies--update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). Ann Hematol 94(9), 1441-1450. Details PubMed
(2015) Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious complications in acute myeloid leukemia. Genes Immun 16(1), 83-88. Details PubMed
(2015) Efficacy of antifungal prophylaxis with oral suspension posaconazole during induction chemotherapy of acute myeloid leukemia. J Cancer Res Clin Oncol 141(9), 1661-1668. Details PubMed
(2014) Treatment with lenalidomide induces immunoactivating and counter-regulatory immunosuppressive changes in myeloma patients. Clin Exp Immunol 177(2), 439-453. Details PubMed
(2014) Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO). Ann Hematol 93(7), 1083-1095. Details PubMed
(2014) Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals. Infection 42(1), 97-9104. Details PubMed
(2014) A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies. J Antimicrob Chemother 69(12), 3387-3392. Details PubMed
(2013) Transient and fully reversible leukocytosis in a myelodysplastic syndrome patient upon initiation of azacitidine treatment. Ann Hematol 92(11), 1577-1579. Details PubMed
(2013) Mixed response to ipilimumab in a melanoma patient with brain metastases: case report and review of the literature. Case Rep Oncol 6(1), 229-235. Details PubMed
(2013) Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood 121(23), 4769-4777. Details PubMed
(2013) Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369(2), 111-121. Details PubMed
(2013) Successful management of Candida krusei monoarthritis after allo-SCT. Bone Marrow Transplant 48(12), 1585-1586. Details PubMed
(2013) Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematological malignancies and solid tumors: guidelines of the Infectious Diseases Working Party (AGIHO) of the DGHO. Ann Hematol 92(4), 433-442. Details PubMed
(2013) Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood 121(1), 170-177. Details PubMed
(2012) Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia. Ann Hematol 91(1), 47-55. Details PubMed
(2012) Diagnosis of chronic disseminated candidosis from liver biopsies by a novel PCR in patients with haematological malignancies. Clin Microbiol Infect 18(10), 1010-1016. Details PubMed
(2012) TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol 30(12), 1350-1357. Details PubMed
(2012) Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood 119(2), 551-558. Details PubMed
(2012) TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood 119(9), 2114-2121. Details PubMed
(2012) Novel treatment concepts for graft-versus-host disease. Blood 119(1), 16-25. Details PubMed
(2011) Plerixafor with and without chemotherapy in poor mobilizers: results from the German compassionate use program. Bone Marrow Transplant 46(8), 1045-1052. Details PubMed
(2011) The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML. Blood 117(7), 2137-2145. Details PubMed
(2011) Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol 29(19), 2709-2716. Details PubMed
(2011) Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology. Ann Oncol 22(5), 1019-1029. Details PubMed
(2011) Clinically defined chemotherapy-associated bowel syndrome predicts severe complications and death in cancer patients. Haematologica 96(12), 1855-1860. Details PubMed