The functional cancer map: a systems-level synopsis of genetic deregulation in cancer.

Krupp M, Maass T, Marquardt JU, Staib F, Bauer T, König R, Biesterfeld S, Galle PR, Tresch A, Teufel A (2011) The functional cancer map: a systems-level synopsis of genetic deregulation in cancer. BMC Med Genomics 4, 53-53. PubMed

Abstract

Cancer cells are characterized by massive dysegulation of physiological cell functions with considerable disruption of transcriptional regulation. Genome-wide transcriptome profiling can be utilized for early detection and molecular classification of cancers. Accurate discrimination of functionally different tumor types may help to guide selection of targeted therapy in translational research. Concise grouping of tumor types in cancer maps according to their molecular profile may further be helpful for the development of new therapeutic modalities or open new avenues for already established therapies.

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doi: 10.1186/1755-8794-4-53 PMID: 21718500