Regulation patterns in signaling networks of cancer.

Schramm G, Kannabiran N, König R (2010) Regulation patterns in signaling networks of cancer. BMC Syst Biol 4, 162. PubMed

Abstract

Formation of cellular malignancy results from the disruption of fine tuned signaling homeostasis for proliferation, accompanied by mal-functional signals for differentiation, cell cycle and apoptosis. We wanted to observe central signaling characteristics on a global view of malignant cells which have evolved to selfishness and independence in comparison to their non-malignant counterparts that fulfill well defined tasks in their sample.

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doi: 10.1186/1752-0509-4-162 PMID: 21110851