Identifying essential genes in bacterial metabolic networks with machine learning methods.

Plaimas K, Eils R, König R (2010) Identifying essential genes in bacterial metabolic networks with machine learning methods. BMC Syst Biol 4, 56. PubMed

Abstract

Identifying essential genes in bacteria supports to identify potential drug targets and an understanding of minimal requirements for a synthetic cell. However, experimentally assaying the essentiality of their coding genes is resource intensive and not feasible for all bacterial organisms, in particular if they are infective.

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doi: 10.1186/1752-0509-4-56 PMID: 20438628