High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status.

Westermann F, Henrich KO, Wei JS, Lutz W, Fischer M, König R, Wiedemeyer R, Ehemann V, Brors B, Ernestus K, Leuschner I, Benner A, Khan J, Schwab M (2007) High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status. Clin Cancer Res 13(16), 4695-4703. PubMed

Abstract

Amplified MYCN oncogene defines a subgroup of neuroblastomas with poor outcome. However, a substantial number of MYCN single-copy neuroblastomas exhibits an aggressive phenotype similar to that of MYCN-amplified neuroblastomas even in the absence of high MYCN mRNA and/or protein levels.

Beteiligte Abteilungen und Gruppen
HKI-Autoren
Identifier

PMID: 17652624