Betty Hebecker
Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

09/2012-05/2016 Wissenschaftliche Mitarbeiterin (PostDoc) im Drittmittelprojekt “Center for Sepsis Control & Care“ Abteilung Mikrobielle Immunologie, HKI, Jena
07–09/2011 Wissenschaftliche Mitarbeiterin (PostDoc), Abteilung Mikrobielle Pathogenitätsmechanismen, HKI, Jena
2007–2011 Doktorandin, Abteilung Mikrobielle Pathogenitätsmechanismen, HKI, Jena
10–12/2007 Wissenschaftliche Mitarbeiterin am Robert-Koch-Institut Berlin, Fachgebiet F16 Mykologie, Arbeitsgruppe Pathogenitätsfaktoren bei Pilzinfektionen
06–10/2006 Wissenschaftliche Mitarbeiterin am Leibniz-Institut für Altersforschung – Fritz-Lipmann-Institut Jena, Abteilung Biochemie
2000–2006 Studium Biologie (Diplom) Friedrich-Schiller-Universität Jena
2005–2006 Diplomarbeit am Max-Planck-Institut für Chemische Ökologie Jena, Abteilung Biochemie

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

2007   DMykG Poster Preis
03-08/2003 ERASMUS Stipendium, Freie Universität Amsterdam, Niederlande
Publikationen

Allert S*, Förster TM*, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B; *authors contributed equally (2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3), e00915. Details PubMed Open Access

Schirbel A, Shouval DS, Hebecker B, Hube B, Sturm A, Werner L (2018) Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha. Eur J Immunol 48(11), 1826-1837. Details PubMed Open Access PDF

Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M (2017) Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLOS ONE 12(10), e0184438. Details PubMed Open Access

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055. Details PubMed Open Access PDF

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68. Details PubMed Open Access

Hebecker B, Naglik JR, Hube B, Jacobsen ID (2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 12(7), 867-879. (Review) Details PubMed

Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother 57(10), 5178-5180. Details PubMed

Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B (2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10(1), 85-93. (Review) Details PubMed

Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B (2012) Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLOS One 7(5), e36952. Details PubMed

Martin R, Wächtler B, Schaller M, Wilson D, Hube B (2011) Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol 301(5), 417-422. (Review) Details PubMed

Naglik JR, Moyes DL, Wächtler B, Hube B (2011) Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect 13(12-13), 963-976. (Review) Details PubMed

Wächtler B, Wilson D, Haedicke K, Dalle F, Hube B (2011) From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLOS One 6(2), e17046. Details PubMed Open Access

Wächtler B, Wilson D, Hube B (2011) Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother 55(9), 4436-4439. Details PubMed

Dalle F, Wächtler B, L'Ollivier C, Holland G, Bannert N, Wilson D, Labruère C, Bonnin A, Hube B (2010) Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol 12(2), 248-271. Details PubMed

Schmidt A, Wächtler B, Temp U, Krekling T, Séguin A, Gershenzon J (2010) A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. Plant Physiol 152(2), 639-655. Details PubMed

Waechtler B, Hube B (2010) Die Phasen des Invasionsprozesses von Candida albicans. DERM (5), 332-336. Details

Wilson D, Thewes S, Zakikhany K, Fradin C, Albrecht A, Almeida R, Brunke S, Grosse K, Martin R, Mayer F, Leonhardt I, Schild L, Seider K, Skibbe M, Slesiona S, Waechtler B, Jacobsen I, Hube B (2009) Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res 9(5), 688-700. (Review) Details PubMed