Sebastian Vlaic

Dr. Sebastian Vlaic

Systembiologie und Bioinformatik

Forschungsschwerpunkte
Systembiologie der Leber
Publikationen

Kaur S, Rawal P, Siddiqui H, Rohilla S, Sharma S, Tripathi DM, Baweja S, Hassan M, Vlaic S, Guthke R, Thomas M, Dayoub R, Bihari C, Sarin SK, Weiss TS (2019) Increased Expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH). Cells 8(10), Details PubMed

Conrad T, Kniemeyer O, Henkel SG, Krüger T, Mattern DJ, Valiante V, Guthke R, Jacobsen ID, Brakhage AA, Vlaic S, Linde J (2018) Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin. BMC System Biol 12(1), 88. Details PubMed Open Access

Rennert C, Vlaic S, Marbach-Breitrück E, Thiel C, Sales S, Shevchenko A, Gebhardt R, Matz-Soja M (2018) The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism – A Systems Biology Analysis Using Self-Organizing Maps. Front Physiol 9, 1180. Details PubMed Open Access

Schaarschmidt B, Vlaic S, Medyukhina A, Neugebauer S, Nietzsche S, Gonnert FA, Rödel J, Singer M, Kiehntopf M, Figge MT, Jacobsen ID, Bauer M, Press AT (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8(14), 3766-3780. Details PubMed Open Access

Schmidt H, Vlaic S, Krüger T, Schmidt F, Balkenhohl J, Dandekar T, Guthke R, Kniemeyer O, Heinekamp T, Brakhage AA (2018) Proteomics of Aspergillus fumigatus conidia-containing phagolysosomes identifies processes governing immune evasion. Mol Cell Proteomics 17(6), 1084-1096. Details PubMed

Vlaic S, Conrad T, Tokarski-Schnelle C, Gustafsson M, Dahmen U, Guthke R, Schuster S (2018) ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks. Sci Rep 8(1), 433. Details PubMed

Christ B, Dahmen U, Herrmann KH, König M, Reichenbach JR, Ricken T, Schleicher J, Ole Schwen L, Vlaic S, Waschinsky N (2017) Computational Modeling in Liver Surgery. Front Physiol 8, 906. (Review) Details PubMed Open Access

Dix A, Vlaic S, Guthke R, Linde J (2016) Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers. Clin Microbiol Infect 22(7), 600-606. Details PubMed Open Access

Guthke R, Gerber S, Conrad T, Vlaic S, Durmus S, Cakir T, Sevilgen E, Shelest E, Linde J (2016) Data-based reconstruction of gene regulatory networks of fungal pathogens. Front Microbiol 7, 570. Details PubMed Open Access

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055. Details PubMed Open Access PDF

Böttger J, Arnold K, Thiel C, Rennert C, Aleithe S, Hofmann U, Vlaic S, Sales S, Shevchenko A, Matz-Soja M (2015) RNAi in murine hepatocytes: the agony of choice--a study of the influence of lipid-based transfection reagents on hepatocyte metabolism. Arch Toxicol 89(9), 1579-1588. Details PubMed

Feuer R, Vlaic S, Arlt J, Sawodny O, Dahmen U, Zanger UM, Thomas M (2015) LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods. PLOS One 10(9), e0135852. Details PubMed

Vlaic S, Altwasser R, Kupfer P, Nilsson CL, Emmett M, Meyer-Baese A, Guthke R (2015) Inference of Predictive Phospho-Regulatory Networks from LC-MS/MS Phosphoproteomics Data In: INSTICC, Portugal (eds.) Communications in Computer and Information Science BIOINFOMATICS 2016 - 7th Int. Conf. Bioinformatics Models, Methods and Algorithms, Rome, Italy, 02/21/2016-02/23/2016, Springer. Details

Kupfer P, Huber R, Weber M, Vlaic S, Häupl T, Koczan D, Guthke R, Kinne RW (2014) Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics 7(1), 40-40. Details PubMed

Altwasser R, Guthke R, Vlaic S, Emmett MR, Conrad CA, Meyer-Baese A (2013) Model order reduction of deterministic and stochastic gene regulatory networks. In: Hamid R. Arabnia, Quoc-Nam Tran (eds.) Proceedings of the International Conference on Bioinformatics and Computational Biology BIOCOMP'13 13th Int. Conf. Bioinformatics and Computational Biology, Las Vegas/USA, 09/16/2012-09/19/2012, pp. 487-496.CSREA Press, USA. ISBN: 1-60132-234-8. Details

Altwasser R, Guthke R, Vlaic S, Emmett MR, Conrad CA, Meyer-Baese A (2013) Almost sure stability of stochastic gene regulatory networks with mode-dependent interval delays. In: Proc. BIOCOMP'13, BIOCOMP'12, Proc. 13th Int. Conf. Bioinformatics and Computational Biology, Las Vegas/USA, 09/16/2012-09/19/2012, pp. 468-477.CSREA Press, Las Vegas, USA. ISBN: 1-60132-234-8. Details

Kupfer P, Vlaic S, Huber R, Kinnne RW, Guthke R (2013) Different stimuli for inference of gene regulatory network in rheumatoid arthritis In: Pedro Fernandes, Jordi Solé-Casals, Ana Fred and Hugo Gamboa (eds.) Bioinformatics 2013 - 4th Int. Conf. on Bioinformatics Models, Methods and Algorithms International Conference on Bioinformatics Models, Methods and Algorithms, Barcelona /Spain, 02/11/2013-02/14/2013, pp. 282-287.SCITEPRESS – Science and Technology Publications, Lissabon /Portugal. ISBN: 978-989-8565358. Details Open Access

Vlaic S, Hoffmann B, Kupfer P, Weber M, Dräger A (2013) GRN2SBML: automated encoding and annotation of inferred gene regulatory networks complying with SBML. Bioinformatics 29(17), 2216-2217. Details PubMed

Weber M, Henkel SG, Vlaic S, Guthke R, van Zoelen EJ, Driesch D (2013) Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0. BMC Syst Biol 7, 1. Details PubMed

Vlaic S, Schmidt-Heck W, Matz-Soja M, Marbach E, Linde J, Meyer-Baese A, Zellmer S, Guthke R, Gebhardt R (2012) The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes. BMC Syst Biol 6, 147. Details PubMed

Werner S, Schroeter A, Schimek C, Vlaic S, Wöstemeyer J, Schuster S (2012) Model of the synthesis of trisporic acid in Mucorales showing bistability. IET Syst Biol 6(6), 207-214. Details PubMed