Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Bjorquist P, Widera A, Stoeber R, Campos G, Hammad S, Sachinidis A, Damm G, Weiss TS, Nussler A, Synnergren J, Edlund K, Küppers-Munther B, Hay D, Hengstler JG (2015) Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. J Hepatol [Epub ahead of print] PubMed

Abstract

The differentiation of stem cells to hepatocyte-like cells (HLC) offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of HLC remains controversial. To obtain an unbiased characterization, we performed a transcriptomics study with HLC derived from human embryonic and induced stem cells (ESC, hiPSC) from three different laboratories.

Beteiligte Abteilungen und Gruppen
HKI-Autoren
Themenfelder
Identifier

doi: S0168-8278(15)00340-2 PMID: 26022688