One ring to fight them all: The sulfazecin story.

Braga D, Lackner G (2017) One ring to fight them all: The sulfazecin story. Cell Chem Biol 24(1), 1-2. (Review) PubMed Open Access

Abstract

In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.

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Identifier

doi: 10.1016/j.chembiol.2017.01.001 PMID: 28107651