The fusarin analogue NG-391 impairs transcription in K-562 leukemia cells
(2013) The fusarin analogue NG-391 impairs transcription in K-562 leukemia cells Phytochemistry Letters 6, 189-192.
Fungi in the genus Metarhizium can infect many insect pests, making them useful for development as insect biological control agents. For microbial strains already in use or under evaluation as biocontrol agents, it is especially important to identify all possible bioactive chemistries that are present in the organism, both from a regulatory standpoint as well as to further understand how various products serve the producing organism. In this paper, we further explored the biological activity of NG391, a compound we previously isolated and identified as a mutagenic toxin. This study explains the biological activity to include cytotoxic activity through a potent effect on nucleic acid biosynthesis. This finding does increase the need to develop a more complete understanding of the factors that regulate expression of these products and especially as they relate to biocontrol activity.