Markus Nett

Dr. habil. Markus Nett

Sekundärmetabolismus räuberischer Bakterien · Abteilungsleiter

Telefon: +49 3641 532-1297 Telefax: +49 3641 532-2927 E-Mail: markus.nett@leibniz-hki.de

Forschungsschwerpunkte
  • Identifizierung und Charakterisierung antimikrobieller Naturstoffe
  • Genome Mining
  • Biosynthese von Antibiotika und Wirkstoff-Engineering
Curriculum vitae

Wissenschaftlicher Werdegang

2014 Gastprofessur für Pharmakognosie, Universität Wien
2014 Habilitation in Pharmazie, Friedrich-Schiller-Universität Jena
seit 2009 Leiter einer Nachwuchsforschergruppe, Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut (HKI) Jena
2007-2008 Wiss. Mitarbeiter, Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, San Diego, USA, gefördert durch ein DAAD-Postdoktoranden-Stipendium
2007 Promotion in Pharmazie, Rheinische Friedrich-Wilhelms-Universität Bonn
2002 Approbation als Apotheker
1997-2001 Studium der Pharmazie, Rheinische Friedrich-Wilhelms-Universität Bonn
Publikationen

Baldeweg F, Hoffmeister D, Nett M (2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria Nat Prod Rep 36(2), 307-325. (Review) Details PubMed

Baldeweg F, Kage H, Schieferdecker S, Allen C, Hoffmeister D, Nett M (2017) Structure of ralsolamycin, the inter-kingdom morphogen of the crop plant pathogen Ralstonia solanacearum GMI1000. Org Lett 19, 4868-4871. Details

Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D (2017) Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase. Angew Chem Int Ed 56(21), 5937-5941. Details PubMed

Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA (2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement

Braga D, Hoffmeister D, Nett M (2016) A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis Beilstein J Org Chem 12, 2766-2770. Details

Kalb D, Heinekamp T, Schieferdecker S, Nett M, Brakhage AA, Hoffmeister D (2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817. Details PubMed

Korp J, Vela Gurovic MS, Nett M (2016) Antibiotics from predatory bacteria. Beilstein J Org Chem 12, 594-607. (Review) Details

Kurth C, Kage H, Nett M (2016) Siderophores as molecular tools in medical and environmental applications. Org Biomol Chem 14(35), 8212-8227. Details PubMed

Kurth C, Schieferdecker S, Athanasopoulou K, Seccareccia I, Nett M (2016) Variochelins, lipopeptide siderophores from Variovorax boronicumulans discovered by genome mining. J Nat Prod 79(4), 865-872. Details PubMed

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuotto M, Roviezzo F, Spaziano G, de Rosa M, Stuppner H, Schuster D, D'Agostino B, Werz O (2016) The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Biochem Pharmacol 112, 60-71. Details PubMed

Schieferdecker S, Nett M (2016) A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A. Tetrahedron Lett 57, 1359-1360. Details

Schwenk D, Brandt P, Blanchette R, Nett M, Hoffmeister D (2016) Unexpected metabolic versatility in a combined fungal fomannoxin/vibralactone biosynthesis. J. Nat. Prod. 79, 1407-1414. Details

Seccareccia I, Kovacs AT, Gallegos-Monterrosa R, Nett M (2016) Unraveling the predator-prey relationship of Cupriavidus necator and Bacillus subtilis. Microbiol Res 192, 231-238. Details

Walther E, Boldt S, Kage H, Lauterbach T, Martin K, Roth M, Hertweck C, Sauerbrei A, Schmidtke M, Nett M (2016) Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties GMS Infect Dis 4, Doc08. Details Open Access

Barnes EC, Bezerra-Gomes P, Nett M, Hertweck C (2015) Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus. J Antibiot (Tokyo) 68, 463-468. Details PubMed

Bauer JS, Ghequire MG, Nett M, Josten M, Sahl HG, De Mot R, Gross H (2015) Biosynthetic origin of the antibiotic pseudopyronines A and B in Pseudomonas putida BW11M1. ChemBioChem 16, 2491-2497. Details

Kage H, Riva E, Parascandolo JS, Kreutzer MF, Tosin M, Nett M (2015) Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase. Org Biomol Chem 13, 11414-11417. Details

Korp J, König S, Schieferdecker S, Dahse H-M, König G M, Werz O, Nett M (2015) Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors. ChemBioChem 16, 2445-2450. Details

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details

Schieferdecker S, Domin N, Hoffmeier C, Bryant DA, Roth M, Nett M (2015) Structure and absolute configuration of auriculamide, a natural product from the predatory bacterium Herpetosiphon aurantiacus. Eur J Org Chem 14, 3057-3062. Details

Schieferdecker S, König S, Koeberle A, Dahse H-M, Werz O, Nett M (2015) Myxochelins target human 5-lipoxygenase. J Nat Prod 78(2), 335-338. Details PubMed

Seccareccia I, Kost C, Nett M (2015) Quantitative analysis of Lysobacter predation. Appl Environ Microbiol 81(20), 7098-7105. Details

Nett M (2014) Genome mining – concept and strategies for natural product discovery. In: Kinghorn DA, Falk H, Kobayashi J (eds.) Prog Chem Org Nat Prod 99, pp. 199-245. Springer, Switzerland. Details

Otzen C, Bardl B, Jacobsen ID, Nett M, Brock M (2014) Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA. J Biol Chem 289(12), 8151-8169. Details PubMed

Schieferdecker S, Exner TE, Gross H, Roth M, Nett M (2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J Antibiot 67(7), 519-525. Details PubMed

Schieferdecker S, König S, Weigel C, Dahse HM, Werz O, Nett M (2014) Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax. Chem Eur J 20, 15933-15940. Details PubMed

Schwenk D, Nett M, Dahse H-M, Horn U, Blanchette RA, Hoffmeister D (2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663. Details PubMed

Elliott CE, Callahan DL, Schwenk D, Nett M, Hoffmeister D, Howlett BJ (2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet Biol 53, 50-58. Details PubMed

Gurovic VMS, Müller S, Domin N, Seccareccia I, Nietzsche S, Martin K, Nett M (2013) Micromonospora schwarzwaldensis sp. nov., a producer of telomycin, isolated from soil. Int J Syst Evol Microbiol 63(Pt 10), 3812-3817. Details PubMed

Kage H, Kreutzer MF, Wackler B, Hoffmeister D, Nett M (2013) An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. Chem Biol 20, 764-771. Details PubMed

Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore BS (2013) Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem 14(8), 955-962. Details PubMed

Pauly J, Spiteller D, Linz J, Jacobs J, Allen C, Nett M, Hoffmeister D (2013) Ralfuranone thioether production by the plant pathogen Ralstonia solanacearum. Chembiochem 14, 2169-2178. Details PubMed

Kastner S, Müller S, Natesan L, König GM, Guthke R, Nett M (2012) 4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence. Arch Microbiol 194(6), 557-566. Details PubMed

Kreutzer MF, Kage H, Nett M (2012) Structure and biosynthetic assembly of cupriachelin, a photoreactive siderophore from the bioplastic producer Cupriavidus necator H16. J Am Chem Soc 134(11), 5415-5422. Details PubMed

Kreutzer MF, Nett M (2012) Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis. Org Biomol Chem 10(47), 9338-9343. Details PubMed

Roth M, Martin K, Zang E, Nett M, Henkel T (2012) A microfluidics-based approach to drug discovery. Biomed Tech (Berl) 57(SI-1 Track-B), 270. Details

Bohnert M, Miethbauer S, Dahse HM, Ziemen J, Nett M, Hoffmeister D (2011) In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg Med Chem Lett 21, 2003-2006. Details PubMed

Kiss H, Nett M, Domin N, Martin K, Maresca JA, Copeland A, Lapidus A, Lucas S, Berry KW, Glavina Del Rio T, Dalin E, Tice H, Pitluck S, Richardson P, Bruce D, Goodwin L, Han C, Detter JC, Schmutz J, Brettin T, Land M, Hauser L, Kyrpides NC, Ivanova N, Göker M, Woyke T, Klenk HP, Bryant DA (2011) Complete genome sequence of the filamentous gliding predatory bacterium Herpetosiphon aurantiacus type strain (114-95(T)). Stand Genomic Sci 5(3), 356-370. Details PubMed

Kreutzer MF, Kage H, Gebhardt P, Wackler B, Saluz HP, Hoffmeister D, Nett M (2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum. Appl Environ Microbiol 77, 6117-6124. Details PubMed

Nett M, Hertweck C (2011) Farinamycin, a quinazoline from Streptomyces griseus. J Nat Prod 74(10), 2265-2268. Details PubMed

Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore BS (2011) Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol 77(11), 3617-3625. Details PubMed

Wackler B, Schneider P, Jacobs JM, Pauly J, Allen C, Nett M, Hoffmeister D (2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol 18, 354-360. Details PubMed

Gomes PB, Nett M, Dahse HM, Hertweck C (2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464. Details PubMed

Nett M, Gulder TA, Kale AJ, Hughes CC, Moore BS (2009) Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem 52(19), 6163-6167. Details PubMed

Nett M, Ikeda H, Moore BS (2009) Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep 26(11), 1362-1384. (Review) Details PubMed

Nett M, Moore BS (2009) Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica Pure Appl Chem 81(6), 1075-1084. (Review) Details

Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B, Lapidus A, Podell S, Allen EE, Moore BS, Jensen PR (2009) Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J 3(10), 1193-1203. Details PubMed

Schneider P, Jacobs JM, Neres J, Aldrich CC, Allen C, Nett M, Hoffmeister D (2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum. Chembiochem 10, 2730-2732. Details PubMed

McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore BS (2008) Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130(25), 7822-7823. Details PubMed

McGlinchey RP, Nett M, Moore BS (2008) Unraveling the biosynthesis of the sporolide cyclohexenone building block. J Am Chem Soc 130(8), 2406-2407. Details PubMed

Nett M, König GM (2007) The chemistry of gliding bacteria. Nat Prod Rep 24(6), 1245-1261. (Review) Details PubMed

Nett M, Erol O, Kehraus S, Köck M, Krick A, Eguereva E, Neu E, König GM (2006) Siphonazole, an unusual metabolite from Herpetosiphon sp. Angew Chem Int Ed Engl 45(23), 3863-3867. Details PubMed

Gross H, Kehraus S, Nett M, König GM, Beil W, Wright AD (2003) New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp. Org Biomol Chem 1(6), 944-949. Details PubMed