
Dr. Sina Gerbach
Transfergruppe Antiinfektiva · Projektmanagement Administration
Telefon: +49 3641 532-1335 Telefax: +49 3641 532-2335 E-Mail: sina.gerbach@leibniz-hki.de
Wissenschaftlicher Werdegang
seit 2016 | Wissenschaftliche Koordination, Leibniz Institut für Naturstoffforschung und Infektionsbiologie - Hans Knöll Institut, Jena |
2011 - 2016 | Postdoc, Prof. P. Bastiaens, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Activity of cMet during liver regeneration |
2009 - 2011 | Postdoc, Prof. L. Claesson-Welsh, Uppsala Universität, Schweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation. |
2008 | Postdoc, Prof. C. Thiede, Universitätsklinikum Dresden |
2003 - 2007 | Promotion, Prof. C. Thiede, Universitätsklinikum Dresden, Thema: Rezeptortyrosinkinase FLT3 in leukämischen Zellen |
2002 | Gastwissenschaftler, Prof. H. Sjöström, Universität Kopenhagen, Dänemark |
2003 | Diplom in Biochemie der Ernährung, Universität Potsdam, Thema: G-Protein-gekoppelte Rezeptor F2alpha |
1997 - 2003 | Studium der Ernährungswissenschaft, Universität Potsdam |
(2018) Hürden und Aussichten neuer antimikrobieller Konzepte in Forschung und Entwicklung. [Obstacles and perspectives of new antimicrobial concepts within research and development]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 61(5), 595-605. Details PubMed PDF
(2016) In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol 1447, 217-242. Details PubMed
(2014) NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev Cell 28(6), 633-646. Details PubMed
(2013) VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 4, 1672. Details PubMed
(2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. J Cell Sci 126(Pt 20), 4746-4755. Details PubMed
(2013) Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hematol 41(5), 444-461.e4. Details PubMed
(2012) Neuropilin signalling in angiogenesis. Biochem Soc Trans 40(1), 20-25. Details PubMed
(2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7), a006502. Details PubMed
(2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437(2), 169-183. Details PubMed
(2011) Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 32(2), 88-8111. Details PubMed
(2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol 38(3), 180-190. Details PubMed
(2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8), 1377-1388. Details PubMed
(2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol 89(7), 653-662. Details PubMed
(2009) Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 113(15), 3568-3576. Details PubMed
(2009) Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J 28(2), 57-65. Details PubMed
(2008) Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs 188(1-2), 225-235. Details PubMed
(2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107(10), 4011-4020. Details PubMed
(2003) On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Adv Exp Med Biol 524, 181-187. Details PubMed
(2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J 371(Pt 2), 443-449. Details PubMed