Thomas Krüger

Dr. Thomas Krüger

Molekulare und Angewandte Mikrobiologie

Telefon: +49 3641 532-1186 Telefax: +49 3641 532-2186 E-Mail: thomas.krueger@leibniz-hki.de

Themenfelder
Publikationen

Misslinger M†, Scheven MT†, Hortschansky P, Sanchez Lopez-Berges M, Heiss K, Beckmann N, Heigl T, Hermann M, Krüger T, Kniemeyer O, Brakhage AA*, Haas H* †shared first authors, *corresponding authors (2019) The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. PLoS Genetics 15(9), e1008379. Details PubMed

Noßmann M, Boysen JM, Krüger T, König CC, Hillmann F, Munder T, Brakhage AA (2019) Yeast two-hybrid screening reveals a dual function for the histone acetyltransferase GcnE by controlling glutamine synthesis and development in Aspergillus fumigatus. Curr Genet 65(2), 523-538. Details PubMed

Satish S, Jiménez-Ortigosa C, Zhao Y, Lee MH, Dolgov E, Krüger T, Park S, Denning DW, Kniemeyer O, Brakhage AA, Perlin DS (2019) Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus. MBio 10(3), pii: e00779-19. Details PubMed

Shekhova E, Ivanova L, Krüger T, Stroe MC, Macheleidt J, Kniemeyer O, Brakhage AA (2019) Redox Proteomic Analysis Reveals Oxidative Modifications of Proteins by Increased Levels of Intracellular Reactive Oxygen Species During Hypoxia Adaptation of Aspergillus fumigatus. Proteomics 19(5), e1800339. Details PubMed

Shopova IA, Belyaev I, Dasari P, Jahreis S, Stroe MC, Cseresnyés Z, Medyukhina A, Svensson CM, Krüger T, Szeifert V, Nietzsche S, Conrad T, Kniemeyer O, Lilienfeld-Toal Mv, Zipfel PF, Ligeti E, Figge MT, Brakhage AA (2019) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. Preprint published on bioRxiv. Details Open Access PDF

Conrad T, Kniemeyer O, Henkel SG, Krüger T, Mattern DJ, Valiante V, Guthke R, Jacobsen ID, Brakhage AA, Vlaic S, Linde J (2018) Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin. BMC System Biol 12(1), 88. Details PubMed Open Access

Hoffmann F, Umbreit C, Krüger T, Pelzel D, Ernst G, Kniemeyer O, Guntinas-Lichius O, Berndt A, von Eggeling F (2018) Identification of Proteomic Markers in Head and Neck Cancer Using MALDI-MS Imaging, LC-MS/MS, and Immunohistochemistry. Proteomics Clin Appl 31(1), e1700173. Details PubMed

Kurucz V, Krüger T, Antal K, Dietl AM, Haas H, Pócsi I, Kniemeyer O, Emri T (2018) Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion. BMC Genomics 19(1), 357. Details PubMed

Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, Ho J, Kichik N, Gaffen SL, Hube B, Naglik JR (2018) Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence. MBio 9(1), pii: e02178-17. Details PubMed Open Access

Schmidt H, Vlaic S, Krüger T, Schmidt F, Balkenhohl J, Dandekar T, Guthke R, Kniemeyer O, Heinekamp T, Brakhage AA (2018) Proteomics of Aspergillus fumigatus conidia-containing phagolysosomes identifies processes governing immune evasion. Mol Cell Proteomics 17(6), 1084-1096. Details PubMed

Thürich J, Meichsner D, Furch ACU, Pfalz J, Krüger T, Kniemeyer O, Brakhage A, Oelmüller R (2018) Arabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis-specific proteins. PLoS One 13(12), e0209658. Details PubMed

Voltersen V, Blango M, Herrmann S, Schmidt F, Heinekamp T, Strassburger M, Krüger T, Bacher P, Lother J, Weiss E, Hünniger K, Liu H, Hortschansky P, Scheffold A, Loeffler J, Krappmann S, Nietzsche S, Kurzai O, Einsele H, Kniemeyer O, Filler S, Reichard U, Brakhage AA (2018) Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus. MBio 9(5), e01557-18. Details PubMed

Luckas B, Krüger T, Röder K (2017) Phycotoxins and Food Safety In: Schrenk, D., Cartus, A. (Ed.) (eds.) Chemical Contaminants and Residues in Food (2017) in: Woodhead Publishing Series in Food Science, Technology and Nutrition 2nd edition. pp. 337-378. Elsevier, Woodhead Publishing. ISBN: 978-0-08-100674. (Review) Details

Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O (2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16. Details PubMed

Shemesh E, Hanf B, Hagag S, Attias S, Shadkchan Y, Fichtman B, Harel A, Krüger T, Brakhage AA, Kniemeyer O, Osherov N (2017) Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants. Front Microbiol 8, 2490. Details PubMed

Zhang T, Wei W, Dirsch O, Krüger T, Kan C, Xie C, Kniemeyer O, Fang H, Settmacher U, Dahmen U (2017) Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury. Int J Mol Sci 18(1), pii: E167. Details PubMed

Kniemeyer O, Ebel F, Krüger T, Bacher P, Scheffold A, Luo T, Strassburger M, Brakhage AA (2016) Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies. Proteomics Clin Appl 10(9-10), 910-921. (Review) Details PubMed

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406. Details PubMed

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68. Details PubMed Open Access

Baldin C, Valiante V, Krüger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA (2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13), 2230-2243. Details PubMed

Heinekamp T, Schmidt H, Lapp K, Pähtz V, Shopova I, Köster-Eiserfunke N, Krüger T, Kniemeyer O, Brakhage AA (2015) Interference of Aspergillus fumigatus with the immune response. Semin Immunopathol 37(2), 141-152. (Review) Details PubMed

Krüger T (2015) Biomarker for Amyotrophic Lateral Sclerosis (Motor Neurone Disease). In: Preedy, V. R., Patel, V. B. (eds.) Biomarkers in Disease: Methods, Discoveries and Applications. General Methods in Biomarker Research and their Applications. Springer. ISBN: 978-94-007-7695. Details

Krüger T, Luo T, Schmidt H, Shopova I, Kniemeyer O (2015) Challenges and Strategies for Proteome Analysis of the Interaction of Human Pathogenic Fungi with Host Immune Cells. Proteomes 3(4), 467-495. (Review) Details

Opitz S, Hannika F, Krüger T, Rhode H (2014) The removal of Triton X-100 by dialysis is feasible! Anal Bioanal Chem 407(4), 1107-1118. Details PubMed