Mirkobielle Symbionten Hydraktinien
Hydraktinien besitzen ein vielfältiges und dynamisches Mikrobiom. Viele assoziierte Bakterien benutzen antimikrobielle Naturstoffe, um den Wirtsorganismus zu schützen und/oder sich gegen Nahrungskonkurrenten zu wehren.
Wir haben wir eine umfangreiche Bakterien und Pilzsammlung von Hydraktinien-assoziierten Mikroorganismen angelegt und die Genome ausgewählter Kandidaten sequenziert. Um zielgerichtet die kodierten Naturstoffen zu identifizieren, benutzen wir eine Kombination aus unterschiedlichen Bioassays, vergleichenden Genomanalysen und state-of-the-art Analytik.
Mikrobielle Symbionten
Mikroorganismen schützen und gestalten den marinen Stachelpolypen Hydraktinia
Naturstoffe aus Hydraktinien und Ihre Symbionten


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(2020) Immunomodulatory function of antimicrobial peptide Ec-Hepcidin1 modulates the induction of inflammatory gene expression in primary cells of caspian trout (Salmo trutta caspius Kessler, 1877). Fish Shellfish Immunol 104, 55-61. PubMed Open Access PDF
(2020) From Persian Gulf to Indonesia: Interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca). Sci Rep 10(1), 13048. PubMed Open Access PDF
(2020) Conus coronatus and Conus frigidus venom: A new source of conopeptides with analgesic activity. Avicenna J Med Biotechnol 12(3), 179-185. PubMed Open Access
(2020) Anti-adipogenic pregnane steroid from a hydractinia-associated fungus, Cladosporium sphaerospermum sp. SW67. Nat Prod Sci 26(3), 230-235. Open Access Code
(2020) Modular solid-phase synthesis of antiprotozoal barnesin derivatives. Org Lett 22(10), 3744-3748. PubMed
(2019) Hybrid polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and their putative biosynthetic origin. Mar Drugs 17(11), 606. PubMed Open Access PDF
(2019) Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67. Org Chem Front 6, 1084-1093.
(2018) Biosynthesis, synthesis and activities of barnesin A, a NRPS-PKS hybrid produced by an anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995. PubMed
(2018) Role of chemical mediators in aquatic interactionas across the prokaryote eukaryote boundary. J Chem Ecol 44(11), 1008-1021. (Review) PubMed Open Access PDF
(2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. PubMed Code
(2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. PubMed
(2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. PubMed
(2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. PubMed
- JSMC (DFG)
Diese Arbeiten finden in enger Kollaboration mit
- dem Biotechnikum (HKI), und der
- Jena Microbial Resource Collection (HKI)
statt.
Dr. Christine Beemelmanns
Leitung
Telefon: +49 3641 532-1525 E-Mail: christine.beemelmanns@leibniz-hki.de
Dr. Jamshid Amiri Moghaddam
Postdoktorand
Telefon: +49 3641 532-1593 E-Mail: jamshid.amiri.moghaddam@leibniz-hki.de