(2004)
Rational saccharide extension by using the natural product glycosyltransferase LanGT4.
Chembiochem 5,
369-371.
Prof. Dr. Dirk Hoffmeister
Pharmazeutische Mikrobiologie · Leiter +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.deCurriculum vitae
Forschungsschwerpunkte
- Biochemische und genetische Grundlagen des pilzlichen Sekundärstoffwechsels
- Naturstoffe aus Basidiomyceten sowie Ralstonia solanacearum
- Mikrobielle Peptidsynthetasen
Wissenschaftlicher Werdegang
| 2014- | W3-Professur Pharmazeutische Mikrobiologie, FSU Jena und HKI Jena |
| 2009-2014 | W2-Professur Pharmazeutische Biologie, FSU Jena und Leiter der Assoziierten Abteilung Pharmazeutische Mikrobiologie am HKI Jena |
| 2007-2009 | Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA |
| 2008 | Habilitation in Pharmazeutischer Biologie und Biotechnologie, Albert-Ludwigs-Universität Freiburg, |
| 2004-2007 | Wiss. Assistent (C1), Institut für Pharmazie, Albert-Ludwigs-Universität Freiburg |
| 2002-2004 | Post-Doc, University of Wisconsin, Madison, WI, USA (DFG-Stipendium) |
| 2002 | Dr. rer. nat., Chemisch-Pharmazeutische Fakultät, Albert-Ludwigs-Universität Freiburg |
| 1998 | Diplom in Biologie an der Eberhard-Karls-Universität Tübingen |
Auszeichnungen · Ämter · wissenschaftliche Aktivitäten
| seit 2020 | Direktor des Institutes für Pharmazie der FSU Jena |
| 2016-2019 | Studiendekan der Biologisch-Pharmazeutischen Fakultät der FSU Jena |
| 2013-2016 | Wiss. Beirat Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM). |
Publikationen
(2004)
Structure-based enzyme engineering and its impact on in vitro glycorandomization.
Chembiochem 5,
16-25.
(2003)
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
J Am Chem Soc 125,
4678-4679.
(2003)
Creation of the first anomeric D/L-sugar kinase by means of directed evolution.
Proc Natl Acad Sci U S A 100,
13184-13189.
(2003)
Procaryotic and eucaryotic cells in biotech production
In: Kayser O, Müller R. H. (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications pp. 9-33. Wiley-Blackwell.
(2003)
Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.
FEMS Microbiol Lett 222,
149-153.
(2003)
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.
Chembiochem 4,
109-111.
(2002)
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.
Chem Biol 9,
287-295.
(2001)
Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.
Chem Biol 8,
557-567.
(2001)
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics.
Chem Biol 8,
569-581.
