(2022)
Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.
ACS Chem Biol 17(2),
386-394.
Luka Raguž
Chemische Biologie der Mikroben-Wirt Interaktionen · Doktorand +49 3641 532-1523 luka.raguz@leibniz-hki.deCurriculum vitae
Forschungsschwerpunkte
- Synthese und Derivatisierung von Naturstoffen
- Synthetische Methodenentwicklung
- Medizinische Chemie
Wissenschaftlicher Werdegang
2016- | Doktorand am Hans-Knöll-Institut |
2013-2016 | Wissenschaftlicher Assistent in der Forschunggruppe von Prof. Riedl an der Zürcher Hochschule für Angewandte Wissenschaften (ZHAW) |
2011-2013 | Masterstudium Life Sciences (ZHAW) |
2008-2011 | Bachelorstudium Chemie (ZHAW) |
2005-2008 | Ausbildung zum Chemielaboranten |
Themenfelder
Publikationen
(2022)
Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition.
Microbiol Spectr 10(5),
e0133122.
(2022)
Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta.
Angew Chem Int Ed 61(41),
e202209105.
(2021)
Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action.
Angew Chem Int Ed 60(28),
15613-15621.
(2021)
Structural and functional analysis of bacterial sulfonosphingolipids and rosette-inducing factor 2 (RIF-2) by mass spectrometry-guided isolation and total synthesis.
Chemistry 28(8),
e202103883.
(2021)
A modular approach to the antifungal Sphingofungin family: Concise total synthesis of Sphingofungin A and C.
Angew Chem Int Ed 61(5),
e202112616.
(2020)
Modular solid-phase synthesis of antiprotozoal barnesin derivatives.
Org Lett 22(10),
3744-3748.
(2019)
Ursprung und Funktionen der Sphingolipide.
Nachrichten aus der Chemie 67(2),
66-70.
(Review)
(2018)
Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins.
ChemBioChem 19(21),
2307-2311.
(2018)
Biosynthesis, synthesis and activities of barnesin A, a NRPS-PKS hybrid produced by an anaerobic Epsilonproteobacterium.
ACS Chem Biol 13(8),
1990-1995.