Sina Gerbach

Dr. Sina Gerbach

Forschungskoordination Transfergruppe Antiinfektiva · Projektmanagement +49 3641 532-1335 sina.gerbach@leibniz-hki.de

Curriculum vitae

Wissenschaftlicher Werdegang
seit 2016 Wissenschaftliche Koordination, Leibniz Institut für Naturstoffforschung und Infektionsbiologie - Hans Knöll Institut, Jena
2011 - 2016 Postdoc, Prof. P. Bastiaens, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Activity of cMet during liver regeneration
2009 - 2011 Postdoc, Prof. L. Claesson-Welsh, Uppsala Universität, Schweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation.
2008 Postdoc, Prof. C. Thiede, Universitätsklinikum Dresden
2003 - 2007 Promotion, Prof. C. Thiede, Universitätsklinikum Dresden, Thema: Rezeptortyrosinkinase FLT3 in leukämischen Zellen
2002 Gastwissenschaftler, Prof. H. Sjöström, Universität Kopenhagen, Dänemark
2003 Diplom in Biochemie der Ernährung, Universität Potsdam, Thema: G-Protein-gekoppelte Rezeptor F2alpha
1997 - 2003 Studium der Ernährungswissenschaft, Universität Potsdam

Themenfelder

Publikationen

Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437(2), 169-183.
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PubMed
Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L (2011) Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 32(2), 88-8111.
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PubMed
Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser M, Ryser M, Brenner S (2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol 38(3), 180-190.
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PubMed
Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L (2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8), 1377-1388.
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PubMed
Stölzel F, Steudel C, Oelschlägel U, Mohr B, Koch S, Ehninger G, Thiede C (2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol 89(7), 653-662.
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PubMed
Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD (2009) Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 113(15), 3568-3576.
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PubMed
Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN (2009) Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J 28(2), 57-65.
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PubMed
Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C (2008) Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs 188(1-2), 225-235.
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PubMed
Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, Ehninger G (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107(10), 4011-4020.
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PubMed
Neuschäfer-Rube F, Engemaier E, Koch S, Böer U, Püschel GP (2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J 371(Pt 2), 443-449.
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PubMed

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