Philipp Stephan

Philipp Stephan

Biosynthetisches Design von Naturstoffen · Doktorand +49 3641 532-1285 philipp.stephan@leibniz-hki.de

Curriculum vitae

Forschungsschwerpunkte
  • Synthese von Naturstoffen und ihren Bausteinen
  • Isolierung und Strukturaufklärung von Naturstoffen

Publikationen

Müll M, Pourmasoumi F, Wehrhan L, Nosovska O, Stephan P, Zeihe H, Vilotijevic I, Keller BG, Kries H (2023) Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S. RSC Chem Biol 4(9), 692-697.
Details
PubMed Open Access PDF Paper
Pourmasoumi F,* Hengoju S,* Beck K, Stephan P, Klopfleisch L, Hoernke M, Rosenbaum MA, Kries H (2023) Analysing megasynthetase mutants at high throughput using droplet microfluidics. Chembiochem 24(24), e202300680.
Details
PubMed Open Access PDF Paper
Stephan P, Langley C, Winkler D, Basquin J, Caputi L, O'Connor SE, Kries H (2023) Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase. Angew Chem Int Ed Engl 62(35), e202304843.
Details
PubMed Open Access PDF Paper PDF Supplement
Stanišić A, Hüsken A, Stephan P, Niquille DL, Reinstein J, Kries H (2021) Engineered nonribosomal peptide synthetase shows opposite amino acid loading and condensation specificity. ACS Catal 11(14), 8692-8700.
Details
Open Access PDF Supplement
Huang HM, Stephan P, Kries H (2020) Engineering DNA-templated nonribosomal peptide synthesis. Cell Chem Biol 28(2), 221-227.
Details
PubMed Open Access
Guo H, Schmidt A, Stephan P, Raguž L, Braga D, Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem 19(21), 2307-2311.
Details
PubMed