Candida albicans scavenges host zinc via Pra1 during endothelial invasion.

Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel PF, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777.

Abstract

The ability of pathogenic microorganisms to assimilate essential nutrients from their hosts is critical for pathogenesis. Here we report endothelial zinc sequestration by the major human fungal pathogen, Candida albicans. We hypothesised that, analogous to siderophore-mediated iron acquisition, C. albicans utilises an extracellular zinc scavenger for acquiring this essential metal. We postulated that such a

Leibniz-HKI-Autoren

Peter F. Zipfel
Bernhard Hube
Matthias Brock
Ilse Denise Jacobsen
Sascha Brunke
Lydia Kasper
Duncan Wilson
Pedro Miramón
Francesco Citiulo

Awards

PLoS Pathogens featured article & recommended by Faculty of 1000: special significance (2x)

Identifier

doi: 10.1371/journal.ppat.1002777

PMID: 22761575