Mark S Gresnigt

Dr. Mark S Gresnigt

Adaptive Pathogenitäts-Strategien · Leiter

Telefon: +49 3641 532-1305 Telefax: +49 3641 532-0810 E-Mail: mark.gresnigt@leibniz-hki.de

Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

Seit
05/2020
Nachwuchsgruppenleiter,  Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans Knöll Institut, Adaptive Pathogenitäts-Strategien
05/2018-
05/2020
Alexander von Humboldt Stiftung Postdoctoral Fellowship, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans Knöll Institut, Abteilung Mikrobielle Pathogenitätsmechanismen, Jena
03/2018-04/2018 Deutsch-Sprachkurs, Dresden
08/2015-03/2018 Postdoktorand, Radboud-Universität, Medizinisches Zentrum. Abteilung Interne Medizin, Nijmegen. Projekt: The development of novel immunomodulatory strategies for disseminated fungal infections
10/2010-05/2015 Phd, Radboud-Universität Nijmegen, Medizinisches Zentrum, Abteilung Interne Medizin. Projekt: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus
02/2008-08/2010 M.Sc. Medizinische Biologie, Radboud-Universität, Nijmegen, Niederlande
07/2003-07/2007 B.Sc. Biologie und Medizinische Forschung, Saxion-Universität der Angewandten Wissenschaften, Enschede, Niederlande

Auszeichnungen · Ämter · wissenschaftliche Aktivitäten

2018 Humboldt-Forschungsstipendium für Postdoktoranden
2018 Preis "Goldene Pipette", Labor für Experimentelle Interne Meizin, Radboud-Universität Nijmegen, Niederlande
2016 Preis für die drittbeste Doktorarbeit, Radboud-Institut für Molekulare Lebenswissenschaften (RIMLS)
2015 Preis für die beste Doktorarbeit, Niederländische Gesellschaft für Immunologie (NVVI)
2015 Nachwuchsförderpreis, Deutschsprachige Mykologische Gesellschaft (DMykG)
2013 ALLFUN Forschungspreis
Publikationen

Austermeier S, Kasper L, Westman J, Gresnigt MS (2020) I want to break free - macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape. Curr Opin Microbiol 58, 15-23. Details PubMed

d'Enfert C, Kaune AK, Alaban LR, Chakraborty S, Cole N, Delavy M, Kosmala D, Marsaux B, Fróis-Martins R, Morelli M, Rosati D, Valentine M, Xie Z, Emritloll Y, Warn PA, Bequet F, Bougnoux ME, Bornes S, Gresnigt MS, Hube B, Jacobsen ID, Legrand M, Leibundgut-Landmann S, Manichanh C, Munro CA, Netea MG, Queiroz K, Roget K, Thomas V, Thoral C, Van den Abbeele P, Walker AW, Brown AJP (2020) The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev [Epub ahead of print] Details PubMed

de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL (2020) Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease. Cytokine 137, 155334. Details PubMed

Kumamoto CA, Gresnigt MS, Hube B (2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15. Details PubMed

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG (2019) The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. Cell Metab 29(1), 211-220.e5. Details PubMed Open Access PDF

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B (2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), dmm039719. Details PubMed Open Access PDF

Grondman I, Arts RJW, Koch RM, Leijte GP, Gerretsen J, Bruse N, Kempkes RWM, Ter Horst R, Kox M, Pickkers P, Netea MG, Gresnigt MS (2019) Frontline science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst. J Leukoc Biol 106(1), 11-25. Details PubMed Open Access PDF

Jaeger M, Matzaraki V, Aguirre-Gamboa R, Gresnigt MS, Chu X, Johnson MD, Oosting M, Smeekens SP, Withoff S, Jonkers I, Perfect JR, van de Veerdonk FL, Kullberg BJ, Joosten LAB, Li Y, Wijmenga C, Netea MG, Kumar V (2019) A genome-wide functional genomics approach identifies susceptibility pathways to fungal bloodstream infection in humans. J Infect Dis 220(5), 862-872. Details PubMed Open Access PDF

Jaeger M, Pinelli M, Borghi M, Constantini C, Dindo M, van Emst L, Puccetti M, Pariano M, Ricaño-Ponce I, Büll C, Gresnigt MS, Wang X, Gutierrez Achury J, Jacobs CWM, Xu N, Oosting M, Arts P, Joosten LAB, van de Veerdonk FL, Veltman JA, Ten Oever J, Kullberg BJ, Feng M, Adema GJ, Wijmenga C, Kumar V, Sobel J, Gilissen C, Romani L, Netea MG (2019) A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Sci Transl Med 11(496), eaar3558. Details PubMed PDF

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. Details PubMed

Assendorp EL, Gresnigt MS, Sprenkeler EGG, Meis JF, Dors N, van der Linden JWM, Henriet SSV (2018) Adjunctive interferon-γ immunotherapy in a pediatric case of Aspergillus terreus infection. Eur J Clin Microbiol Infect Dis 37(10), 1915-1922. Details PubMed

Gresnigt MS, Becker KL, Leenders F, Alonso MF, Wang X, Meis JF, Bain JM, Erwig LP, van de Veerdonk FL (2018) Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis. J Innate Immun 10(2), 145-160. Details PubMed

Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Malireddi RKS, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, Jong DJ, Lacerda JF, Campos A, Melchers WJG, Lagrou K, Maertens J, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL (2018) Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun 9(1), 2636. Details PubMed Open Access PDF

Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B (2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun 9(1), 4260. Details PubMed Open Access

Workum JD, de Jong SW, Gresnigt MS, Becker KL, Pickkers P, van de Veerdonk FL, Heijdra YF, Kolwijck E (2018) Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient. Med Mycol Case Rep 21, 4-7. Details PubMed

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM (2017) Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infect Dis 17(12), e393-e402. Details PubMed

Arts RJ, Gresnigt MS, Joosten LA, Netea MG (2017) Cellular metabolism of myeloid cells in sepsis. J Leukoc Biol 101(1), 151-164. Details PubMed

Dewi IMW, van de Veerdonk FL, Gresnigt MS (2017) The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus. J Fungi (Basel) 3(4), Details PubMed

Domínguez-Andrés J, Arts RJW, Ter Horst R, Gresnigt MS, Smeekens SP, Ratter JM, Lachmandas E, Boutens L, van de Veerdonk FL, Joosten LAB, Notebaart RA, Ardavín C, Netea MG (2017) Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis. PLoS Pathog 13(9), e1006632. Details PubMed

Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers WJG, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL (2017) The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression. Front Immunol 8, 1777. Details PubMed

Leentjens J, Gresnigt MS, van de Veerdonk FL, Kox M, Kullberg BJ, Pickkers P, Brouwer AE, Netea MG (2017) Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses. Int J Infect Dis 59, 25-28. Details PubMed

Matzaraki V, Gresnigt MS, Jaeger M, Ricaño-Ponce I, Johnson MD, Oosting M, Franke L, Withoff S, Perfect JR, Joosten LAB, Kullberg BJ, van de Veerdonk FL, Jonkers I, Li Y, Wijmenga C, Netea MG, Kumar V (2017) An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS One 12(7), e0180824. Details PubMed

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA (2017) A guiding map for inflammation. Nat Immunol 18(8), 826-831. Details PubMed

Raijmakers RPH, Sprenkeler EGG, Aleva FE, Jacobs CWM, Kanneganti TD, Joosten LAB, van de Veerdonk FL, Gresnigt MS (2017) Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics. Sci Rep 7(1), 11500. Details PubMed

van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latgé JP (2017) Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol 15(11), 661-674. Details PubMed

van de Veerdonk FL, Gresnigt MS, Verweij PE, Netea MG (2017) Personalized medicine in influenza: a bridge too far or the near future? Curr Opin Pulm Med 23(3), 237-240. Details PubMed

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G (2016) Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe 19(1), 79-90. Details PubMed

Becker KL, Aimanianda V, Wang X, Gresnigt MS, Ammerdorffer A, Jacobs CW, Gazendam RP, Joosten LA, Netea MG, Latgé JP, van de Veerdonk FL (2016) Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway. mBio 7(3), Details PubMed

Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17(4), 406-413. Details PubMed

Gresnigt MS, Rekiki A, Rasid O, Savers A, Jouvion G, Dannaoui E, Parlato M, Fitting C, Brock M, Cavaillon JM, van de Veerdonk FL, Ibrahim-Granet O (2016) Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor. Sci Rep 6, 26490. Details PubMed

Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG (2016) Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells. Eur J Immunol 46(11), 2574-2586. Details PubMed

Lasonder E, Rijpma SR, van Schaijk BC, Hoeijmakers WA, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW (2016) Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression. Nucleic Acids Res 44(13), 6087-6101. Details PubMed

Sprenkeler EG, Gresnigt MS, van de Veerdonk FL (2016) LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus. Cell Microbiol 18(9), 1208-1216. Details PubMed

Ammerdorffer A, Schoffelen T, Gresnigt MS, Oosting M, den Brok MH, Abdollahi-Roodsaz S, Kanneganti TD, de Jong DJ, van Deuren M, Roest HJ, Rebel JM, Netea MG, Joosten LA, Sprong T (2015) Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Infect Dis 211(6), 978-987. Details PubMed

Becker KL, Gresnigt MS, Smeekens SP, Jacobs CW, Magis-Escurra C, Jaeger M, Wang X, Lubbers R, Oosting M, Joosten LA, Netea MG, Reijers MH, van de Veerdonk FL (2015) Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients. Clin Exp Allergy 45(2), 423-437. Details PubMed

Buddingh EP, Leentjens J, van der Lugt J, Dik WA, Gresnigt MS, Netea MG, Pickkers P, Driessen GJ (2015) Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis. Pediatr Infect Dis J 34(12), 1391-1394. Details PubMed

Smeekens SP, Gresnigt MS, Becker KL, Cheng SC, Netea SA, Jacobs L, Jansen T, van de Veerdonk FL, Williams DL, Joosten LA, Dinarello CA, Netea MG (2015) An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. Cytokine 71(2), 215-222. Details PubMed

Wójtowicz A, Gresnigt MS, Lecompte T, Bibert S, Manuel O, Joosten LA, Rüeger S, Berger C, Boggian K, Cusini A, Garzoni C, Hirsch HH, Weisser M, Mueller NJ, Meylan PR, Steiger J, Kutalik Z, Pascual M, van Delden C, van de Veerdonk FL, Bochud PY (2015) IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation. J Infect Dis 211(10), 1646-1657. Details PubMed

de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL (2014) IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A 111(9), 3526-3531. Details PubMed

Delsing CE, Gresnigt MS, Leentjens J, Preijers F, Frager FA, Kox M, Monneret G, Venet F, Bleeker-Rovers CP, van de Veerdonk FL, Pickkers P, Pachot A, Kullberg BJ, Netea MG (2014) Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series. BMC Infect Dis 14, 166. Details PubMed

Gresnigt MS, Bozza S, Becker KL, Joosten LA, Abdollahi-Roodsaz S, van der Berg WB, Dinarello CA, Netea MG, Fontaine T, De Luca A, Moretti S, Romani L, Latge JP, van de Veerdonk FL (2014) A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog 10(3), e1003936. Details PubMed

Gresnigt MS, van de Veerdonk FL (2014) The role of interleukin-1 family members in the host defence against Aspergillus fumigatus. Mycopathologia 178(5-6), 395-401. Details PubMed

van de Veerdonk FL, Gresnigt MS, Oosting M, van der Meer JW, Joosten LA, Netea MG, Dinarello CA (2014) Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37. Front Microbiol 5, 762. Details PubMed

van Poppel PC, Gresnigt MS, Smits P, Netea MG, Tack CJ (2014) The dipeptidyl peptidase-4 inhibitor vildagliptin does not affect ex vivo cytokine response and lymphocyte function in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 103(3), 395-401. Details PubMed

Gresnigt MS, Becker KL, Smeekens SP, Jacobs CW, Joosten LA, van der Meer JW, Netea MG, van de Veerdonk FL (2013) Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3. J Immunol 190(11), 5629-5639. Details PubMed

Gresnigt MS, Rösler B, Jacobs CW, Becker KL, Joosten LA, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL (2013) The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. Eur J Immunol 43(2), 416-426. Details PubMed

Gresnigt MS, van de Veerdonk FL (2013) Biology of IL-36 cytokines and their role in disease. Semin Immunol 25(6), 458-465. Details PubMed

Kyrmizi I, Gresnigt MS, Akoumianaki T, Samonis G, Sidiropoulos P, Boumpas D, Netea MG, van de Veerdonk FL, Kontoyiannis DP, Chamilos G (2013) Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling. J Immunol 191(3), 1287-1299. Details PubMed

Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ (2013) Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nat Commun 4, 1342. Details PubMed

Gresnigt MS, Joosten LA, Verschueren I, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL (2012) Neutrophil-mediated inhibition of proinflammatory cytokine responses. J Immunol 189(10), 4806-4815. Details PubMed

Gresnigt MS, Netea MG, van de Veerdonk FL (2012) Pattern recognition receptors and their role in invasive aspergillosis. Ann N Y Acad Sci 1273, 60-67. Details PubMed

Smeekens SP, Henriet SS, Gresnigt MS, Joosten LA, Hermans PW, Netea MG, Warris A, van de Veerdonk FL (2012) Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease. J Interferon Cytokine Res 32(4), 159-168. Details PubMed

van de Veerdonk FL, Gresnigt MS, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG (2009) Th17 responses and host defense against microorganisms: an overview. BMB Rep 42(12), 776-787. Details PubMed

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