Teresa Lehnert

Dr. Teresa Lehnert

Angewandte Systembiologie

Forschungsschwerpunkte
  • Computersimulation von virtuellen Infektionsmodellen
  • populationsbasierte, zustandsbasierte und agentenbasierte Modellierung
  • Anwendung globaler Optimierungsalgorithmen zur Schätzung von unbekannten Modellparametern
Themenfelder
Curriculum vitae

Wissenschaftlicher Werdegang

seit 2016 Wissenschaftliche Mitarbeiterin in der Gruppe Angewandte Systembiology am Hans-Knöll-Institut
2017 Dr. rer. nat. in Bioinformatik an der Friedrich-Schiller-Universität Jena
2011 Diplom in Bioinformatik an der Friedrich-Schiller-Universität Jena
Publikationen

Lehnert T*, Leonhardt I*, Timme S, Thomas-Rüddel D, Bloos F, Sponholz C, Kurzai O, Figge MT** ,Hünniger K**; * shared first authors; ** authors contributed equally (2020) Ex vivo Immune profiling in patient blood enables quantification of innate immune effector functions. bioRxiv , Details Open Access PDF

Sreekantapuram S*, Lehnert T*, Prauße MT, Berndt A, Berens C, Figge MT**, Jacobsen ID**; * authors contributed equally; ** corresponding authors (2020) Dynamic interplay of host and pathogens in an avian whole blood model. Front Immunol 11, 500. Details PubMed Open Access PDF

Tille A, Lehnert T, Zipfel PF, Figge MT (2020) Quantification of factor H mediated self versus non-self discrimination by mathematical modeling. Front Immunol 11, 1911. Details

Prauße MTE, Lehnert T, Timme S, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560. Details PubMed Open Access PDF Supplement

Timme S, Lehnert T, Prauße MTE, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667. Details PubMed Open Access PDF Supplement

Lehnert T, Figge MT (2017) Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling. Front Immunol 8, 1692. Details PubMed Open Access PDF Supplement

Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O (2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276. Details PubMed

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo R, Riedemann N, Kurzai O (2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210. Details PubMed

Lehnert T*, Timme S*, Pollmächer J, Hünniger K, Kurzai O, Figge MT (2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally. Details PubMed Open Access

Hünniger K*, Lehnert T*, Bieber K, Martin R, Figge MT⁺, Kurzai O⁺ (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally. Details PubMed Open Access

Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed

Links