In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy.

Jacobsen ID, Lüttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796. PubMed

Abstract

Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal fungal burden as cfu is commonly used. However, this approach provides only a snapshot of the current situation in an individual animal and cryptic sites of infection may easily be missed. Thus, we aimed to develop real-time non-invasive imaging to monitor infection in vivo.

Beteiligte Abteilungen und Gruppen

Mikrobielle Pathogenitätsmechanismen Fungal Septomics Mikrobielle Immunologie Mikrobielle Biochemie und Physiologie

HKI-Autoren

Prof. Dr. Bernhard Hube Dr. habil. Matthias Brock Prof. Dr. Oliver Kurzai Prof. Dr. Ilse Denise Jacobsen Dr. Anja Wartenberg (née Lüttich)

Identifier

doi: 10.1093/jac/dku198 PMID: 24951534