(2024)
Engineering adhesion of the probiotic strain Escherichia coli nissle to the fungal pathogen Candida albicans.
ACS Synth Biol
[Epub ahead of print]
Dr. Gerald Lackner
Synthetische Mikrobiologie · Leiter +49 3641 532-1104 gerald.lackner@leibniz-hki.deCurriculum vitae
Wissenschaftlicher Werdegang
2016 -today | Junior Group Leader |
2014 - 2016 | PostDoc (Feodor Lynen Research Fellowship) ETH Zurich (Jörn Piel) Research focus: Genomics of uncultured natural product producers, biosynthesis of ribosomally produced small molecules |
2011 - 2014 | PostDoc FSU Jena (Dirk Hoffmeister) Research focus: Polyketide and nonribosomal peptide biosynthesis in mushrooms. |
2006 - 2011 | PhD student HKI Jena (Christian Hertweck) Research focus: Genomics of natural product-producing bacterial endosymbionts of fungi. |
2001 - 2006 | Studies of Biochemistry FSU, Jena |
Publikationen
(2024)
Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction.
ISME J 18(1),
wrae074.
(2023)
Analysis of rhizonin biosynthesis reveals origin of pharmacophoric furylalanine moieties in diverse cyclopeptides.
Angew Chem Int Ed 62(42),
e202308540.
(2023)
Basidiomycete non-reducing polyketide synthases function independently of SAT domains.
Fungal Biol Biotechnol 10(1),
17.
(2022)
S‐Adenosylmethionine (SAM)-dependent methyltransferase MftM is responsible for methylation of the redox cofactor mycofactocin.
ACS Chem Biol 17(11),
3207-3217.
(2022)
Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F420 and its derivative 3PG-F420.
mBio 13(1),
e03501-21.
(2022)
High-yield production of coenzyme F420 in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space.
Metab Eng 73,
158-167.
(2021)
Comparative genomic and metabolic analysis of Streptomyces sp. RB110 morphotypes illuminates genomic rearrangements and formation of a new 46-membered antimicrobial macrolide.
ACS Chem Biol 16(8),
1482-1492.
(2020)
Biosynthesis of the redox coenzyme F420 in Thermomicrobia involves reduction by standalone nitroreductase superfamily enzymes.
Appl Environ Microbiol 86(12),
e00457-20.
(2020)
Injury-triggered blueing reactions of Psilocybe "magic" mushrooms.
Angew Chem Int Ed 59(4),
1450-1454.