Curriculum vitae

Forschungsschwerpunkte
  • Chinonsynthetasen und verwandte Enzyme
  • Polyketidsynthasen aus Ständerpilzen
  • Biosynthese von Psilocybin
  • Inhaltsstoffe der Gattung Psilocybe
Wissenschaftlicher Werdegang
2014- W3-Professur Pharmazeutische Mikrobiologie, FSU Jena und HKI Jena
2009-2014 W2-Professur Pharmazeutische Biologie, FSU Jena und Leiter der Assoziierten Abteilung Pharmazeutische Mikrobiologie am HKI Jena
2007-2009 Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008 Habilitation in Pharmazeutischer Biologie und Biotechnologie, Albert-Ludwigs-Universität Freiburg, 
2004-2007 Wiss. Assistent (C1), Institut für Pharmazie, Albert-Ludwigs-Universität Freiburg 
2002-2004 Post-Doc, University of Wisconsin, Madison, WI, USA (DFG-Stipendium)
2002 Dr. rer. nat., Chemisch-Pharmazeutische Fakultät, Albert-Ludwigs-Universität Freiburg 
1998 Diplom in Biologie an der Eberhard-Karls-Universität Tübingen
Auszeichnungen · Ämter · wissenschaftliche Aktivitäten
seit 2020 Direktor des Institutes für Pharmazie der FSU Jena
2016-2019 Studiendekan der Biologisch-Pharmazeutischen Fakultät der FSU Jena
2013-2016 Wiss. Beirat Vereinigung für   Allgemeine und Angewandte Mikrobiologie (VAAM).

Publikationen

Hoffmeister D, Yang J, Liu L, Thorson JS (2003) Creation of the first anomeric D/L-sugar kinase by means of directed evolution. Proc Natl Acad Sci U S A 100, 13184-13189.
Pelzer S, Hoffmeister D, Merfort I, Bechthold A (2003) Procaryotic and eucaryotic cells in biotech production In: Kayser O, Müller R. H. (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications pp. 9-33. Wiley-Blackwell.
Rebets Y, Ostash B, Luzhetskyy A, Hoffmeister D, Brana A, Mendez C, Salas JA, Bechthold A, Fedorenko V (2003) Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol Lett 222, 149-153.
Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J (2003) Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem 4, 109-111.
Hoffmeister D, Wilkinson B, Foster G, Sidebottom PJ, Ichinose K, Bechthold A (2002) Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol 9, 287-295.
Hoffmeister D, Ichinose K, Bechthold A (2001) Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. Chem Biol 8, 557-567.
Weitnauer G, Mühlenweg A, Trefzer A, Hoffmeister D, Süssmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A (2001) Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chem Biol 8, 569-581.
Faust B, Hoffmeister D, Weitnauer G, Westrich L, Haag S, Schneider P, Decker H, Künzel E, Rohr J, Bechthold A (2000) Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717. Microbiology 146 ( Pt 1), 147-154.
Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A (2000) The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. Chem Biol 7, 821-831.
Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A (2000) Function of glycosyltransferase genes involved in urdamycin A biosynthesis. Chem Biol 7, 133-142.