Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba.

Macabeo APG, Letada AG, Budde S, Faderl C, Dahse HM, Franzblau SG, Alejandro GJD, Pierens GK, Garson MJ (2017) Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba. J Nat Prod 80(12), 3319-3323.

Abstract

Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 μM) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 μM, respectively.

Leibniz-HKI-Autor*innen

Hans-Martin Dahse

Identifier

doi: 10.1021/acs.jnatprod.7b00679

PMID: 29172496