Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome.

Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE (2016) Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome. J Allergy Clin Immunol 138(4), 1161-11169.e6.

Abstract

TH17 cells have so far been considered to be crucial mediators of autoimmune inflammation. Two distinct types of TH17 cells have been described recently, which differed in their polarization requirement for IL-1β and in their cytokine repertoire. Whether these distinct TH17 phenotypes translate into distinct TH17 cell functions with implications for human health or disease has not been addressed yet.

Leibniz-HKI-Autoren

Christina Zielinski

Identifier

doi: S0091-6749(16)00266-9

PMID: 27040374