Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen.

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C (2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177.

Abstract

Caught in the act: imaging mass spectrometry of a button mushroom infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.

Leibniz-HKI-Autor*innen

Martin Roth
Gerald Lackner

Identifier

doi: 10.1002/anie.201206658

PMID: 23161559