Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714.

Heine D, Martin K, Hertweck C (2014) Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714. J Nat Prod 77(4), 1083-1087.

Abstract

In this study we report on the genomics-guided exploration of the metabolic potential of the newly discovered strain Kitasatospora sp. HKI 714. The bioinformatics analysis of the whole genome sequence revealed the presence of a biosynthetic gene cluster presumably responsible for the biosynthesis of formerly unknown endophenazine derivatives. A 200 L cultivation combined with bioactivity-guided isolation techniques revealed four new natural products belonging to the endophenazines and the 5,10-dihydrophenazines. Detailed descriptions of their biological effects, mainly focused on antimicrobial properties against several mycobacteria, are given.

Leibniz-HKI-Autor*innen

Daniel Heine
Christian Hertweck
Karin Martin

Identifier

doi: 10.1021/np400915p

PMID: 24617951