Dr. Sascha Brunke
Telefon: +49 3641 532-1222 Telefax: +49 3641 532-0810 E-Mail: firstname.lastname@example.org
(2021) Experimental evolution of Candida by serial passaging in host cells. Methods Mol Biol 2260, 145-154.
(2021) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J 15, 1257-1270.
(2021) Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans. Cell Microbiol [Accepted]
(2021) Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells. Nat Microbiol 6(5), 643-657.
(2021) Rational design of an antifungal polyacrylamide library with reduced host-cell toxicity. ACS Appl Mater Interfaces 13(23), 27430-27444.
(2021) Transient mitochondria dysfunction confers fungal cross-resistance against phagocytic killing and fluconazole. mBio 12(3), e0112821.
(2021) A TRP1-marker-based system for gene complementation, overexpression, reporter gene expression, and gene modification in Candida glabrata. FEMS Yeast Res 20(8), foaa066.
(2021) The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization. Virulence 12(1), 329-345.
(2021) Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria. Comput Struct Biotechnol J 19, 1244-1252.
(2020) Wettrüsten zwischen Pilz und Wirt. BIOSpektrum 26(3), 280-286. (Review)
(2020) Survival strategies of pathogenic Candida species in human blood show independent and specific adaptations. mBio 11(5), e02435-20.
(2020) Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11(2), e00206-20.
(2020) Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome 8(1), 133.
(2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6), 1340-1355.
(2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19.
(2019) RNAi as a tool to study virulence in the pathogenic yeast Candida glabrata. Front Microbiol 10, 1679.
(2019) Phagocytic predation by the fungivorous amoeba Protostelium aurantium targets metal ion and redox homeostasis. bioRxiv 690503, preprint.
(2019) Antivirulence and avirulence genes in human pathogenic fungi. Virulence 10(1), 935-947. (Review)
(2018) The needle and the damage done. Nat Microbiol 3(8), 860-861. (Review)
(2018) Metals in fungal virulence. FEMS Microbiol Rev 42(1), fux050. (Review)
(2018) Power spectrum consistency among systems and transducers. Ultrasound Med Biol 44(11), 2358-2370.
(2018) Comparative study on alternative splicing in human fungal pathogens suggests its involvement during host invasion. Front Microbiol 9, 2313.
(2018) Two's company: studying interspecies relationships with dual RNA-seq. Curr Opin Microbiol 42, 7-12. (Review)
(2017) The fungal pathogen Candida glabrata does not depend on surface ferric reductases for iron acquisition. Front Microbiol 8, 1055.
(2017) Encapsulation of antifungals in micelles protects Candida albicans during gall-bladder infection. Front Microbiol 8, 117.
(2017) The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans. Mol Microbiol 104(6), 989-1007.
(2017) Candida albicans Hap43 domains are required under iron starvation but not excess. Front Microbiol 8, 2388.
(2016) In vivo transcriptional profiling of human pathogenic fungi during infection: reflecting the real life? PLOS Pathog 12(4), e1005471. (Review)
(2016) Candida species rewired hyphae developmental programs for chlamydospore formation. Front Microbiol 7, 1697.
(2016) Virulence factors in fungal pathogens of man. Curr Opin Microbiol 32, 89-95. (Review)
(2016) A novel hybrid iron regulation network combines features from pathogenic and non-pathogenic yeasts. mBio 7(5), e01782-16.
(2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055.
(2016) Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a Zinc depletion response. Front Microbiol 7, 750.
(2016) Widespread inter- and intra-Ddmain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Front Microbiol 7, 2001.
(2015) Csr1/Zap1 maintains zinc homeostasis and influences virulence in Candida dubliniensis but is not coupled to morphogenesis. Eukaryot Cell 14(7), 661-670.
(2015) Of mice, flies - and men? Comparing fungal infection models for large-scale screening efforts. Dis Model Mech (8), 473-486.
(2015) Metal ions in host microbe interactions: The microbe perspective. In: Nriagu JO, Skaar EP (eds.) Trace Metals and Infectious Diseases. The MIT Press. Strüngmann Forum Reports. ISBN: 9780262029193.
(2015) Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase, and morphology. J Med Microbiol 64, 714-723.
(2014) Adaptive prediction as a strategy in microbial infections. PLOS Pathog 10(10), e1004356.
(2014) One small step for a yeast - Microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation. PLOS Pathog 10(10), e1004478.
(2014) Histidine degradation via an aminotransferase increases the nutritional flexibility of Candida glabrata. Eukaryot Cell 13(6), 758-765.
(2014) Metabolism in Fungal Pathogenesis. Cold Spring Harb Perspect Med 4(12),
(2014) Fine-scale chromosomal changes in fungal fitness. J Curr Fungal Infect Rep Vol. 8(2), 171-178. (Review)
(2014) Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLOS One 9(5), e96015.
(2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PLOS One 9(3), e92734.
(2014) Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLOS Pathog 10(6), e1004211.
(2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13(1), 170-183.
(2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLOS Genet 10(12), e1004824.
(2013) Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol 15(5), 701-708. (Review)
(2013) Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney. PLOS One 8(5), e64482.
(2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLOS One 8(3), e58613.
(2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777.
(2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10(1), 85-93. (Review)
(2012) Isolation and amplification of fungal RNA for microarray analysis from host samples. In: Brand AC, MacCallum DM (eds.) Methods in Molecular Biology. Host-fungus interactions. Methods and Protocols. 845, pp. 411-421. Humana Press (Springer).
(2012) An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells. Front Microbiol 3, 85.
(2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 187(6), 3072-3086.
(2010) Candida glabrata tryptophan-based pigment production via the Ehrlich pathway. Mol Microbiol 76(1), 25-47.
(2010) Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy. Infect Immun 78(3), 1066-1077.
(2009) Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459(7247), 657-662.
(2009) Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology. Med Mycol 47(3), 248-258.
(2009) Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res 9(5), 688-700. (Review)
(2008) The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLOS Pathog 4(11), e1000217.
(2006) MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur. Microbiology 152(Pt 2), 547-554.