Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks.

Westergaard D, Li J, Jensen K, Kouskoumvekaki I, Panagiotou G (2014) Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks. BMC Genomics 15, 380. PubMed

Abstract

Epidemiological studies in the recent years have investigated the relationship between dietary habits and disease risk demonstrating that diet has a direct effect on public health. Especially plant-based diets -fruits, vegetables and herbs- are known as a source of molecules with pharmacological properties for treatment of several malignancies. Unquestionably, for developing specific intervention strategies to reduce cancer risk there is a need for a more extensive and holistic examination of the dietary components for exploring the mechanisms of action and understanding the nutrient-nutrient interactions. Here, we used colon cancer as a proof-of-concept for understanding key regulatory sites of diet on the disease pathway.

HKI-Autoren
Identifier

doi: 10.1186/1471-2164-15-380 PMID: 24886433