Sina Gerbach

Dr. Sina Gerbach

Forschungskoordination Transfergruppe Antiinfektiva · Projektmanagement +49 3641 532-1335 sina.gerbach@leibniz-hki.de

Curriculum vitae

Wissenschaftlicher Werdegang
seit 2016 Wissenschaftliche Koordination, Leibniz Institut für Naturstoffforschung und Infektionsbiologie - Hans Knöll Institut, Jena
2011 - 2016 Postdoc, Prof. P. Bastiaens, Max-Planck-Institut für Molekulare Physiologie, Dortmund, Activity of cMet during liver regeneration
2009 - 2011 Postdoc, Prof. L. Claesson-Welsh, Uppsala Universität, Schweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation.
2008 Postdoc, Prof. C. Thiede, Universitätsklinikum Dresden
2003 - 2007 Promotion, Prof. C. Thiede, Universitätsklinikum Dresden, Thema: Rezeptortyrosinkinase FLT3 in leukämischen Zellen
2002 Gastwissenschaftler, Prof. H. Sjöström, Universität Kopenhagen, Dänemark
2003 Diplom in Biochemie der Ernährung, Universität Potsdam, Thema: G-Protein-gekoppelte Rezeptor F2alpha
1997 - 2003 Studium der Ernährungswissenschaft, Universität Potsdam

Themenfelder

Publikationen

Kloss F, Gerbach S (2018) Hürden und Aussichten neuer antimikrobieller Konzepte in Forschung und Entwicklung. [Obstacles and perspectives of new antimicrobial concepts within research and development]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 61(5), 595-605. (Review)
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Koch S, Helbing I, Böhmer SA, Hayashi M, Claesson-Welsh L, Söderberg O, Böhmer FD (2016) In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol 1447, 217-242.
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Koch S, van Meeteren LA, Morin E, Testini C, Weström S, Björkelund H, Le Jan S, Adler J, Berger P, Claesson-Welsh L (2014) NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev Cell 28(6), 633-646.
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Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Koh GY, Dejana E, Belting HG, Affolter M, Thurston G, Holmgren L, Vestweber D, Claesson-Welsh L (2013) VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 4, 1672.
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Köthe S, Müller JP, Böhmer SA, Tschongov T, Fricke M, Koch S, Thiede C, Requardt RP, Rubio I, Böhmer FD (2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. J Cell Sci 126(Pt 20), 4746-4755.
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Ortlepp C, Steudel C, Heiderich C, Koch S, Jacobi A, Ryser M, Brenner S, Bornhäuser M, Brors B, Hofmann WK, Ehninger G, Thiede C (2013) Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hematol 41(5), 444-461.e4.
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Koch S (2012) Neuropilin signalling in angiogenesis. Biochem Soc Trans 40(1), 20-25.
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Koch S, Claesson-Welsh L (2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7), a006502.
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Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437(2), 169-183.
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Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L (2011) Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 32(2), 88-8111.
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